All Phenotypes Nr1h3<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr1h3^tm1Dgen
targeted mutation 1, Deltagen
MGI:3664445

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1h3^tm1Dgen/Nr1h3^tm1Dgen	Not Specified	MGI:3688386

Allelic Composition	Nr1h3^tm1Dgen/Nr1h3^tm1Dgen
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h3^tm1Dgen mutation (0 available); any Nr1h3 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:112995 )

• high-cholesterol fed mutants infused with tauroursodeoxycholate to determine maximal secretory rates for biliary lipids exhibit slightly higher bile flows and a 200% increase in hepatobiliary excretion of phospholipids compared to wild-type but similar cholesterol secretion rates

abnormal cholesterol homeostasis ( J:112995 )

• cholesterol feeding increases hepatobiliary cholesterol (sterol ester) excretion to a higher level than in wild-type

liver/biliary system

abnormal hepatobiliary system physiology ( J:112995 )

• cholesterol feeding increases hepatobiliary cholesterol (sterol ester) excretion to a higher level than in wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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