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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Htttm5Szi
targeted mutation 5, Scott Zeitlin
MGI:3663764
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Htttm4Szi/Htttm5Szi involves: 129S1/Sv MGI:3664661
cn2
Htttm4Szi/Htttm5Szi
Tg(Hsp70-1-cre)1Arge/0
involves: 129S1/Sv * C57BL/6J * CBA MGI:3664662


Genotype
MGI:3664661
ht1
Allelic
Composition
Htttm4Szi/Htttm5Szi
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm4Szi mutation (0 available); any Htt mutation (36 available)
Htttm5Szi mutation (0 available); any Htt mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• conditional mice lacking Hdh are fertile, have normal life spans and are indistinguishable from wild-type littermates




Genotype
MGI:3664662
cn2
Allelic
Composition
Htttm4Szi/Htttm5Szi
Tg(Hsp70-1-cre)1Arge/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm4Szi mutation (0 available); any Htt mutation (36 available)
Htttm5Szi mutation (0 available); any Htt mutation (36 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• E8.5 embryos are developmentally retarded in appearance compared to wild-type; embryonic portion of conceptus is small and stubby with no obvious head folds and somites are absent
• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed

embryo
• E8.5 embryos are developmentally retarded in appearance compared to wild-type
• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed
• embryonic portion of conceptus is small and stubby with no obvious head folds
• at E8.5

growth/size/body
• E8.5 embryos are developmentally retarded in appearance compared to wild-type
• at E9.5, embryos display a slight increase in size, but the embryonic portion has begun to be resorbed





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory