All Phenotypes Lrp5<tm1Lex> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp5^tm1Lex/Lrp5^tm1Lex	involves: 129/Sv * C57BL/6J * FVB/N	MGI:3664570
ht2	Lrp5^tm1Lex/Lrp5⁺	involves: 129/Sv * C57BL/6J * FVB/N	MGI:3664571
cx3	Lrp5^tm1Lex/Lrp5⁺ Lrp6^Gt(Ex187)Byg/Lrp6⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:3664573
cx4	Lrp5^tm1Lex/Lrp5^tm1Lex Lrp6^Gt(Ex187)Byg/Lrp6⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:3664576
cx5	Lrp5^tm1Lex/Lrp5^tm1Lex Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:3664577

Allelic Composition	Lrp5^tm1Lex/Lrp5^tm1Lex
Genetic Background	involves: 129/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Lex mutation (0 available); any Lrp5 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mineral density ( J:111359 )

• homozygotes have lower bone mineral density (BMD) than wild-type or heterozygous littermates; differences become significant at 29 days of age and persists thereafter

vision/eye

persistence of hyaloid vascular system ( J:111359 )

• mutants display this abnormality in eye vascularization

Allelic Composition	Lrp5^tm1Lex/Lrp5⁺
Genetic Background	involves: 129/Sv * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Lex mutation (0 available); any Lrp5 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mineral density ( J:111359 )

• significantly reduced vs wild-type; present in all regions examined so values are not disproportionately reduced in animals with limb defects

abnormal trabecular bone morphology ( J:111359 )

• mice have decreased trabecular bone volume fraction (bone volume/tissue volume) compared to wild-type

Allelic Composition	Lrp5^tm1Lex/Lrp5⁺ Lrp6^Gt(Ex187)Byg/Lrp6⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1Lex mutation (0 available); any Lrp5 mutation (81 available)
Lrp6^Gt(Ex187)Byg mutation (1 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:111359 )

• mice display incompletely penetrant limb deformities (35% of mice), which follows a pattern of severity along both left-right and posterior-anterior axes; some animals have apparently normal limbs while others have a completely absent limb(s)

forelimb oligodactyly ( J:111359 )

• in affected mice, typically digits 4 and/or 5 are missing in the forelimb

abnormal forelimb morphology ( J:111359 )

• 27% have affected right forelimbs while 1% have affected left forelimbs; 7% have both affected; none of these mice show hindlimb defects

skeleton

decreased bone mineral density ( J:111359 )

• significantly reduced vs wild-type; present in all regions examined so values are not disproportionately reduced in animals with limb defects

decreased bone mass ( J:111359 )

• Lrp6 heterozygosity exacerbates the low bone mass phenotype

synostosis ( J:111359 )

• most animals present between extremes of normal limbs vs absence of entire limb with either synostosis or reduction deformity of postaxial digits

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:111359 )

abnormal carpal bone morphology ( J:111359 )

• significantly reduced vs wild-type; present in all regions examined so values are not disproportionately reduced in animals with limb defects

monodactyly ( J:111359 )

• often only one digit is present on hindlimbs of affected mice

forelimb oligodactyly ( J:111359 )

• in affected mice, typically digits 4 and/or 5 are missing in the forelimb

abnormal tarsal bone morphology ( J:111359 )

• in hindlimbs, the talus, calcaneous, and other tarsal bones are malformed or absent

abnormal forelimb morphology ( J:111359 )

• 27% have defects in both forelimbs while 9% have defects in both forelimbs and in the right hindlimb

• defects are more severe in right forelimb vs left forelimb

abnormal hindlimb morphology ( J:111359 )

skeleton

abnormal cranium morphology ( J:111359 )

• in 3 month old animals, skulls display reduced BMD when skull thickness is examined

abnormal carpal bone morphology ( J:111359 )

• significantly reduced vs wild-type; present in all regions examined so values are not disproportionately reduced in animals with limb defects

abnormal tarsal bone morphology ( J:111359 )

• in hindlimbs, the talus, calcaneous, and other tarsal bones are malformed or absent

decreased bone mineral density ( J:111359 )

• significantly reduced vs wild-type; present in all regions examined so values are not disproportionately reduced in animals with limb defects

decreased bone mass ( J:111359 )

• Lrp6 heterozygosity exacerbates the low bone mass phenotype

synostosis ( J:111359 )

• most animals present between extremes of normal limbs vs absence of entire limb with either synostosis or reduction deformity of postaxial digits

craniofacial

abnormal cranium morphology ( J:111359 )

• in 3 month old animals, skulls display reduced BMD when skull thickness is examined

Allelic Composition	Lrp5^tm1Lex/Lrp5^tm1Lex Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mineral density ( J:111359 )

• significantly reduced vs wild-type; present in all regions examined so values are not disproportionately reduced in animals with limb defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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