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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptprgtm1Shar
targeted mutation 1, Sheila Harroch
MGI:3663183
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptprgtm1Shar/Ptprgtm1Shar involves: 129S6/SvEvTac * C57BL/6 MGI:3663266


Genotype
MGI:3663266
hm1
Allelic
Composition
Ptprgtm1Shar/Ptprgtm1Shar
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprgtm1Shar mutation (0 available); any Ptprg mutation (113 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• working memory and contextual fear responses are comparable to conrols; null mice do not show altered susceptibility to pharmacologically-induced seizures
• mice show reduced performance in cued fear conditioning tests
• in tail-suspension test, mutants show a longer latency to first immobilization; however, total immobility times are comparable to controls
• null mice display reduced latencies vs wild-type in a tail flick test, but have normal pain and shock thresholds
• mutants show improved pre-pulse inhibition compared to wild-type in an auditory stimulus test
• null mice show significant motor deficits as assessed by the rotarod and hanging wire tests, although muscle strength is comparable to wild-type





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory