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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ins2-Fas*I246N)1Ach
transgene insertion 1, Alexander V Chervonsky
MGI:3662920
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0
NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach MGI:3663041
tg2
Tg(Ins2-Fas*I246N)1Ach/0 NOD-Tg(Ins2-Fas*I246N)1Ach MGI:3663020


Genotype
MGI:3663041
cx1
Allelic
Composition
Tg(Ins2-Fas*I246N)1Ach/0
Tg(Ins2-Fasl)24Ach/0
Genetic
Background
NOD-Tg(Ins2-Fas*I246N)1Ach Tg(Ins2-Fasl)24Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fas*I246N)1Ach mutation (1 available)
Tg(Ins2-Fasl)24Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• double transgenics show slower onset of diabetes compared to NOD-Tg(Ins2-Fasl)24Ach single transgenics

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:81416




Genotype
MGI:3663020
tg2
Allelic
Composition
Tg(Ins2-Fas*I246N)1Ach/0
Genetic
Background
NOD-Tg(Ins2-Fas*I246N)1Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-Fas*I246N)1Ach mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• transgenic mice show some level of protection against spontaneous diabetes, correlating with level of transgene expression
• onset of diabetes in slightly delayed in mice injected with diabetic T cells compared to NOD controls (16 days vs 13 days) or Fasl transgenic mice (16 days vs 5 days)





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory