About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc40a1ffe
flatiron
MGI:3662903
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc40a1ffe/Slc40a1ffe involves: 129X1/SvJ * C57BL/6J MGI:3700663
hm2
Slc40a1ffe/Slc40a1ffe involves: C3H/HeJ * C57BL/6J MGI:3700662
ht3
Slc40a1ffe/Slc40a1+ either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) MGI:3700665


Genotype
MGI:3700663
hm1
Allelic
Composition
Slc40a1ffe/Slc40a1ffe
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1ffe mutation (1 available); any Slc40a1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mid-gestational lethality

hematopoietic system
• severe anemia

homeostasis/metabolism
N
• Background Sensitivity: generalized edema is not seen in mice crossed onto a 129X1/SvJ background, unlike mice on a mixed background including C3H/HeJ

nervous system
N
• Background Sensitivity: no neural tube defects are seen in mice crossed onto a 129X1/SvJ background, unlike mice on a mixed background including C3H/HeJ
• Background Sensitivity: forebrain truncations are not seen in mice crossed onto a 129X1/SvJ background, unlike mice on a mixed background including C3H/HeJ

vision/eye
N
• Background Sensitivity: microphthalmia is not seen in mice crossed onto a 129X1/SvJ background, unlike mice on a mixed background including C3H/HeJ




Genotype
MGI:3700662
hm2
Allelic
Composition
Slc40a1ffe/Slc40a1ffe
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1ffe mutation (1 available); any Slc40a1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mid-gestational lethality

hematopoietic system
• severe anemia

homeostasis/metabolism
• Background Sensitivity: generalized edema is seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background

nervous system
• Background Sensitivity: neural tube closure defects are seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background
• Background Sensitivity: forebrain truncations are seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background

vision/eye
• Background Sensitivity: microphthalmia is seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background

embryo
• Background Sensitivity: neural tube closure defects are seen on a mixed background including C3H/HeJ but not in mice crossed onto 129X1/SvJ background




Genotype
MGI:3700665
ht3
Allelic
Composition
Slc40a1ffe/Slc40a1+
Genetic
Background
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1ffe mutation (1 available); any Slc40a1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• serum ferritin levels are increased 10-fold compared to wild-type mice at 6 months of age and levels continue to increase with age
• at 6 months of age transferrin saturation in serum is much lower than in wild-type mice
• aged mice accumulate high levels of iron in Kupffer cells

hematopoietic system
• mild anemia
• some hypochromic red cells are present in blood smears
• some hypochromic red cells with variable size are present in blood smears
• some target cells are present in blood smears
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells

immune system
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells

liver/biliary system
• aged mice accumulate high levels of iron in Kupffer cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hemochromatosis type 4 DOID:0111028 OMIM:606069
J:118592





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory