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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gnpnat1tm1Mak
targeted mutation 1, Tak Mak
MGI:3662646
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gnpnat1tm1Mak/Gnpnat1tm1Mak either: (involves: C57BL/6J) or (involves: CD-1) MGI:3662893


Genotype
MGI:3662893
hm1
Allelic
Composition
Gnpnat1tm1Mak/Gnpnat1tm1Mak
Genetic
Background
either: (involves: C57BL/6J) or (involves: CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnpnat1tm1Mak mutation (0 available); any Gnpnat1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are present at E6.5 but die by E7.5; only empty yolk sacs, occasionally with a remnant of allantois, are found at E8.5 or E9.5
• no homozygotes are detected at E10.5-E12.5

embryo
• at E6.5, mutants resemble E5.5 wild-type embryos
• exocoel is absent or corrupted in mutants at E7.5
• at E6.5, ~50% of mutants display a small ectoplacental cone
• absent or corrupted in mutants at E7.5
• absent or corrupted in mutants at E7.5
• absent or corrupted in mutants at E7.5

growth/size/body
• at E6.5, mutants resemble E5.5 wild-type embryos

cellular
• mutant erythroid bodies (EB) display only 24-79% of cellularity observed for wild-type ES cells in the absence of LIF





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory