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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rettm1Kln
targeted mutation 1, Rudiger Klein
MGI:3662623
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Rettm1Kln/Rettm1Kln
Tg(Nes-cre)1Kln/0
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL MGI:3662906
cn2
Lhx1tm1Tmj/Lhx1+
Rettm1Kln/Rettm1Kln
Tg(Nes-cre)1Kln/0
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL MGI:3662908
cn3
Rettm1Kln/Rettm1Kln
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv MGI:5440833


Genotype
MGI:3662906
cn1
Allelic
Composition
Rettm1Kln/Rettm1Kln
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Kln mutation (1 available); any Ret mutation (53 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants have peroneal nerves (PN) of reduced length (~40% of control) at E11.5 and nerves are reduced in complexity at E12.5; diameter of peroneal nerve is also reduced
• phenotype at E12.5 is somewhat less severe than in Rettm1Kln; Tg(Pgk1-cre)1Lni mice

limbs/digits/tail
• clubbed feet are observed in mutants after birth

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
clubfoot DOID:11836 OMIM:119800
J:110955




Genotype
MGI:3662908
cn2
Allelic
Composition
Lhx1tm1Tmj/Lhx1+
Rettm1Kln/Rettm1Kln
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129/Sv * BALB/c * C57BL/6 * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (22 available)
Rettm1Kln mutation (1 available); any Ret mutation (53 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve
• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls
• phenotype of mice is more severe than in wild-type Lhx1 background

cellular
• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve
• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls
• phenotype of mice is more severe than in wild-type Lhx1 background




Genotype
MGI:5440833
cn3
Allelic
Composition
Rettm1Kln/Rettm1Kln
Slc6a3tm1(cre)Xz/Slc6a3+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Kln mutation (1 available); any Ret mutation (53 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• late-onset, progressive
• deficits in elicited dopamine release





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory