Phenotypes associated with this allele
nervous system
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• mutants have peroneal nerves (PN) of reduced length (~40% of control) at E11.5 and nerves are reduced in complexity at E12.5; diameter of peroneal nerve is also reduced
• phenotype at E12.5 is somewhat less severe than in Rettm1Kln; Tg(Pgk1-cre)1Lni mice
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limbs/digits/tail
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• clubbed feet are observed in mutants after birth
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Tmj mutation
(0 available);
any
Lhx1 mutation
(22 available)
Rettm1Kln mutation
(1 available);
any
Ret mutation
(53 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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nervous system
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• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve
• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls
• phenotype of mice is more severe than in wild-type Lhx1 background
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cellular
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• peroneal nerve at E12.5 is rerouted to the path of the tibial nerve
• trajectory of small branch emerging from PN in mutants does not match stereotyped path of dorsal growing PN axons in controls
• phenotype of mice is more severe than in wild-type Lhx1 background
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nervous system
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• late-onset, progressive
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• deficits in elicited dopamine release
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