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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(H2-K-Cd86)27All
transgene insertion 27, James P Allison
MGI:3656476
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cd28tm1Pjl/Cd28tm1Pjl
Tg(H2-K-Cd86)27All/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3662645
cx2
 		Tcrbtm1Mom/Tcrbtm1Mom
Tg(H2-K-Cd86)27All/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3662647
cx3
 		B2mtm1Jae/B2mtm1Jae
Tg(H2-K-Cd86)27All/0 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3662644
cx4
 		Faslpr/Faslpr
Tg(H2-K-Cd86)27All/0 		involves: C57BL/6 * CBA * MRL/MpJ MGI:3662636
tg5
 		Tg(H2-K-Cd86)27All/0 involves: C57BL/6J * CBA MGI:3662648


Genotype
MGI:3662645
cx1
Allelic
Composition		 Cd28tm1Pjl/Cd28tm1Pjl
Tg(H2-K-Cd86)27All/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Pjl mutation (0 available); any Cd28 mutation (53 available)
Tg(H2-K-Cd86)27All mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:112475 )
• transgenic mice deficient in Cd28 express normal numbers of peripheral B lymphocytes in contrast to Tg(H2-K-Cd86)27All mice

immune system
decreased B cell number ( J:112475 )
• transgenic mice deficient in Cd28 express normal numbers of peripheral B lymphocytes in contrast to Tg(H2-K-Cd86)27All mice




Genotype
MGI:3662647
cx2
Allelic
Composition		 Tcrbtm1Mom/Tcrbtm1Mom
Tg(H2-K-Cd86)27All/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (94 available)
Tg(H2-K-Cd86)27All mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:112475 )
N
• mice have same numbers of B cells in spleen and lymph nodes as control littermates




Genotype
MGI:3662644
cx3
Allelic
Composition		 B2mtm1Jae/B2mtm1Jae
Tg(H2-K-Cd86)27All/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Jae mutation (8 available); any B2m mutation (122 available)
Tg(H2-K-Cd86)27All mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent B cells ( J:112475 )
• no B cells are detected in blood of B2m-deficient transgenic mice

immune system
absent B cells ( J:112475 )
• no B cells are detected in blood of B2m-deficient transgenic mice




Genotype
MGI:3662636
cx4
Allelic
Composition		 Faslpr/Faslpr
Tg(H2-K-Cd86)27All/0
Genetic
Background		 involves: C57BL/6 * CBA * MRL/MpJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Tg(H2-K-Cd86)27All mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:112475 )
• frequency and absolute number of B lymphocytes in primary and secondary lymphoid organs are very low

immune system
decreased B cell number ( J:112475 )
• frequency and absolute number of B lymphocytes in primary and secondary lymphoid organs are very low




Genotype
MGI:3662648
tg5
Allelic
Composition		 Tg(H2-K-Cd86)27All/0
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:112475 )
• B cells are slightly larger and express higher levels of MHC class II than wild-type
• proportion of pre/pro B cells and immature/mature B cells is drastically reduced in bone marrow in transgenic mice
decreased B cell number ( J:112475 )
• mice expressing the transgene at moderate levels show a substantial reduction in B lymphocytes in all peripheral tissues

immune system
abnormal B cell differentiation ( J:112475 )
• B cells are slightly larger and express higher levels of MHC class II than wild-type
• proportion of pre/pro B cells and immature/mature B cells is drastically reduced in bone marrow in transgenic mice
decreased B cell number ( J:112475 )
• mice expressing the transgene at moderate levels show a substantial reduction in B lymphocytes in all peripheral tissues




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory