Analysis Tools
mortality/aging
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• die around midgestation
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cardiovascular system
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• from E9.5 myofibrils fail to grow laterally however Z-disc and M-band structure is maintained through E10
• by E11 sarcomeres are disassembled with only a few disarrayed filaments remaining
• however, no increase in cardiac hypertrophic response-related genes expression is seen
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• at E10 trabeculation is reduced; however heart looping is normal
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• at E10
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• at E11 the ventricular wall is unstable and atrophic
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• seen at E11 associated with atrophy and instability of the ventricular wall
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embryo
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• by E10.5, apoptosis is increased throughout the embryo particularly around the peritoneal cavity, this appears to be secondary to impaired cardiac function
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• detected at E11 by reduced size and a decrease in the number of somites
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• at E9.5 both the head and body are reduced in size
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cellular
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• by E10.5, apoptosis is increased throughout the embryo particularly around the peritoneal cavity, this appears to be secondary to impaired cardiac function
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growth/size/body
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• detected at E11 by reduced size and a decrease in the number of somites
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• at E9.5 both the head and body are reduced in size
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muscle
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• from E9.5 myofibrils fail to grow laterally however Z-disc and M-band structure is maintained through E10
• by E11 sarcomeres are disassembled with only a few disarrayed filaments remaining
• however, no increase in cardiac hypertrophic response-related genes expression is seen
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• at E10 trabeculation is reduced; however heart looping is normal
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• at E10
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homeostasis/metabolism
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• seen at E11 associated with atrophy and instability of the ventricular wall
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