Phenotypes associated with this allele

• Allele Symbol: Rab3gap1^tm1Tkss
• Allele Name: targeted mutation 1, Takuya Sasaki
• Allele ID: MGI:3654149
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab3gap1^tm1Tkss/Rab3gap1^tm1Tkss	involves: 129X1/SvJ * C57BL/6	MGI:3654634

Genotype
MGI:3654634

hm1

• Allelic Composition: Rab3gap1^tm1Tkss/Rab3gap1^tm1Tkss
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:111069 )

• hippocampal CA1 synapses show larger facilitation with almost no depression following repetitive stimulation at a moderate frequency (25 times at 14 Hz)

abnormal neurotransmitter secretion ( J:111069 )

• following KCl-induced depolarization Ca-dependent glutamate release from synaptosomes is impaired

enhanced paired-pulse facilitation ( J:111069 )

• in CA1 synapses the magnitude of paired-pulse facilitation is increased at 50, 70, and 100 ms intervals

• however, there does not appear to be a difference in the baseline release probability, long term potentiation, or post-tetanic potential and no morphological abnormalities are seen in the cerebral cortex or hippocampus