Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Zjc mutation
(1 available);
any
Mavs mutation
(36 available)
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immune system
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• severely decreased type I IFN serum levels after infection with influenza A virus
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Zjc mutation
(1 available);
any
Mavs mutation
(36 available)
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immune system
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• interferon induction in conventional dendritic cells when stimulated with Sendai virus; plasmacytoid dendritic cells show normal interferon levels in response viral infection and LPS response is normal in both types of dendritic cells
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• MEFs from mutant mice display impaired innate immunity when infected with Sendai virus; interferon production and Il-6 production is defective; Il-6 induction is normal however when mice are stimulated with LPS
• induction of interferon alpha and beta (Ifna, Ifnb respectively) is abolished in the first 4 hours after injection of poly(I:C) and production of Il-6 is impaired in this period; there is a late induction of Il-6 at reduced levels after 4 hours
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• isolated bone-marrow derived and peripheral macrophages do not show induction of IFNalpha, IFNbeta, and Il-6 or activation of NF-kappaB by Sendai virus; response to LPS is normal though
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• all homozygotes (and heterozygotes) die within 4 days of infection with VSV (vesicular stomatitis virus) while wild-type survive; with infection by 2 x 108 of the less virulent VSV-GFP, all homozygotes die within 8 days while 5/7 wild-type survive 12 days and infection with _ the viral titer, 50% of homozygotes survive to day 12
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hematopoietic system
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• isolated bone-marrow derived and peripheral macrophages do not show induction of IFNalpha, IFNbeta, and Il-6 or activation of NF-kappaB by Sendai virus; response to LPS is normal though
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Allelic
Composition |
Mavstm1Zjc/Mavs+
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Genetic
Background |
involves: 129/Sv * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Zjc mutation
(1 available);
any
Mavs mutation
(36 available)
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immune system
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• intermediate levels of IFNalpha, IFNbeta and Il-6 are found in the sera of heterozygotes after injection of poly(I:C)
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• all heterozygotes die within 4 days of infection with VSV (vesicular stomatitis virus) while wild-type survive; with infection by 2 x 108 of the less virulent VSV-GFP, 2/5 heterozygotes survive 8 days while 5/7 wild-type survive 12 days and infection with half the viral titer, 3 out of 4 survive past 12 days
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Zjc mutation
(1 available);
any
Mavs mutation
(36 available)
Rnaseh2atm1Crh mutation
(0 available);
any
Rnaseh2a mutation
(45 available)
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mortality/aging
immune system
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• E14.5 mouse embryo fibroblasts show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes
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Analysis Tools