Analysis Tools
homeostasis/metabolism
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• after 18 hours of water deprivation, urine osmolality increases from 1860 to 2720 mosmol/ kg water in wild-type mice, but little increase is seen in tamoxifen-treated mutants
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• after tamoxifen-induced deletion of Aqp2. osmolality of urine in mutants decreases from ~2000 mosmol/kg water to <500 mosmol/kg water by 4-5 days after tamoxifen injection and remains low at ~ 200 mosmol/kg water
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renal/urinary system
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• after 18 hours of water deprivation, urine osmolality increases from 1860 to 2720 mosmol/ kg water in wild-type mice, but little increase is seen in tamoxifen-treated mutants
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• after tamoxifen-induced deletion of Aqp2. osmolality of urine in mutants decreases from ~2000 mosmol/kg water to <500 mosmol/kg water by 4-5 days after tamoxifen injection and remains low at ~ 200 mosmol/kg water
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• dilatation of collecting ducts in the renal cortex and medulla is observed in kidneys 6 weeks after induction resulting from polyuria
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• 6 weeks after induction, many kidneys show medullary atrophy
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hydroureter
(
J:110648
)
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• seen in mice 6 weeks after tamoxifen induction
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• seen in mice 6 weeks after tamoxifen induction
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• after tamoxifen treatment, mice are severely polyuric, excreting ~10-fold greater fluid than controls
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