Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
Htr2atm2Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
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behavior/neurological
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• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors
• home cage activity did not differ
• motor coordination, strength, and sensory processing were unimpaired
• baseline concentrations and the rise in corticosterone release following anxiety tests were comparable
• cell number, mantel thickness, barrel field formation, or the expression of GABA containing neuronal markers are normal
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• explored the lit compartment to a greater extent in the dark-light choice test
• explored the riskier portions of the elevated plus-maze to a greater extent
• exhibited a shorter latency to begin feeding in a novel environment
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
Htr2atm2Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
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behavior/neurological
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• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation
(1 available);
any
Emx1 mutation
(34 available)
Htr2atm1Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
Htr2atm2Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
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behavior/neurological
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N |
• selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors
• exhibited wild-type levels of anxiety-like behavior as measured by the open field test, dark-light choice test, and novelty suppressed feeding paradigm
• depression-related paradigms, such as the forced swim test and tail suspension test, were unchanged compared to un-restored homozygous null litter mate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2atm1Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
Htr2atm2Grch mutation
(0 available);
any
Htr2a mutation
(42 available)
Slc6a4tm1(cre)Grch mutation
(0 available);
any
Slc6a4 mutation
(51 available)
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behavior/neurological
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• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test
• selective restoration of 5HT2AR signaling to the thalamus did not normalized conflict anxiety behaviors
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Analysis Tools