Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
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immune system
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• activated T cells show dramatically increased response to CXCL9 and CXCL11, and a lesser increased response to CXCL10 in vitro, relative to wild-type cells; GTPgammaS membrane incorporation is significantly increased in response to CXCR3 agonist stimulation, correlating with enhanced chemotaxis
• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls
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hematopoietic system
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• activated T cells show dramatically increased response to CXCL9 and CXCL11, and a lesser increased response to CXCL10 in vitro, relative to wild-type cells; GTPgammaS membrane incorporation is significantly increased in response to CXCR3 agonist stimulation, correlating with enhanced chemotaxis
• CXCL12-evoked chemotactic responses are diminished compared to wild-type controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
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Fusion of lumbar vertebrae in Gnai3tm1Lbi/Gnai3tm1Lbi mice
skeleton
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• one mouse has the eighth rib ectopically attached to the sternum
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• a single mouse lacking rib fusions had small triangular outgrowths of cartilage at the distal end of the second rib pair
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• Background Sensitivity: fusions of the cartilaginous portion of the distal ribs are seen in 95% of mice on a 129S/SvEv background but in less than 40% of mice on a mixed 129S/SvEv and C57BL/6 background
• Background Sensitivity: the average number of fusions is reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background
• fusions typically involve only ribs that articulate with the sternum
• ectopic connection of the eighth rib to the sternum is seen in 1 case
• fusions are detected as early as E14.5
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• Background Sensitivity: incidence of lumbar defects in reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background
• deformation or partial fusion of one or more vertebral bodies in 9 of 10 mice in the lumbar region
• in 2 of 10 pups pointed outgrowths that do not fuse are detected
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• in 7 of 10 pups a small bridge of bone connecting the bodies of two or three adjacent vertebrae is present
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
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Fusion of lumbar vertebrae in Gnai3tm1Lbi/Gnai3tm1Lbi mice
skeleton
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• Background Sensitivity: fusions of the cartilaginous portion of the distal ribs are seen in 95% of mice on a 129S/SvEv background but in less than 40% of mice on a mixed 129S/SvEv and C57BL/6 background
• Background Sensitivity: the average number of fusions is reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background
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• Background Sensitivity: incidence of lumbar defects in reduced in mice on a mixed 129S/SvEv and C57BL/6 background compared to mice on a 129S/SvEv background
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immune system
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• OVA-induced tissue accumulation of eosinophils is normal
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Rib fusion phenotype is enhanced in Gnai3tm1Lbi/Gnai3tm1Lbi mice by loss of Gnai2 in cartilage
skeleton
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• rib fusions are more severe compared to mice homozygous for Gnai3tm1Lbi alone
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• not noticeably more severe than in mice homozygous for Gnai3tm1Lbi alone
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skeleton
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• rib fusions are more severe compared to mice homozygous for Gnai3tm1Lbi alone
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Lbi mutation
(0 available);
any
Gnai2 mutation
(54 available)
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
Tg(Myog-cre)1Eno mutation
(0 available)
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Rib fusion phenotype is enhanced in Gnai3tm1Lbi/Gnai3tm1Lbi mice by loss of Gnai2 in cartilage
skeleton
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• rib fusions are similar in severity to mice homozygous for Gnai3tm1Lbi alone
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1tm1Drs mutation
(0 available);
any
Gnai1 mutation
(15 available)
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
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Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3
immune system
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• decrease in IL-10 production from peritoneal monocytes after in vitro lipopolysaccharide-induction
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• increase in TNFa production from spleen monocytes after in vitro lipopolysaccharide-induction
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homeostasis/metabolism
skeleton
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• rib fusions are more frequent and severe compared to mice homozygous for Gnai3tm1Lbi alone
• rib fusions frequently involve both true and false ribs
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• not noticeably more severe than in ice homozygous for Gnai3tm1Lbi alone
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai1tm1Drs mutation
(0 available);
any
Gnai1 mutation
(15 available)
Gnai3tm1Lbi mutation
(1 available);
any
Gnai3 mutation
(28 available)
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Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3
skeleton
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• rib fusions are more frequent and severe compared to mice homozygous for Gnai3tm1Lbi alone
• rib fusions frequently involve both true and false ribs
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• not noticeably more severe than in mice homozygous for Gnai3tm1Lbi alone
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Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3
skeleton
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• one mouse has the eighth rib ectopically attached to the sternum
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Analysis Tools