Phenotypes associated with this allele

• Allele Symbol: Igkc^tm1Bgmn
• Allele Name: targeted mutation 1, Marianne Bruggemann
• Allele ID: MGI:3652576
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igkc^tm1Bgmn/Igkc^tm1Bgmn	involves: 129P2/OlaHsd	MGI:3652818
cx2	Ighm^tm1Cgn/Ighm^tm1Cgn Igkc^tm1Bgmn/Igkc^tm1Bgmn Igl^tm2.1Bgmn/Igl^tm2.1Bgmn	involves: 129	MGI:3806699
cx3	Igkc^tm1Bgmn/Igkc^tm1Bgmn Igl^tm2.1Bgmn/Igl^tm2.1Bgmn	involves: 129P2/OlaHsd	MGI:3806697
cx4	Ighm^tm3Bgmn/Ighm^tm3Bgmn Igkc^tm1Bgmn/Igkc^tm1Bgmn Igl^tm2.1Bgmn/Igl^tm2.1Bgmn	involves: 129P2/OlaHsd * 129/Sv	MGI:3806698
cx5	Igkc^tm1Bgmn/Igkc^tm1Bgmn Igl^tm1.1Bgmn/Igl^tm1.1Bgmn	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA	MGI:3702894
cx6	Igkc^tm1Bgmn/Igkc^tm1Bgmn Igl^tm1Bgmn/Igl^tm1Bgmn	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA	MGI:3702900
cx7	Igkc^tm1Bgmn/Igkc^tm1Bgmn Igl^tm2Bgmn/Igl^tm2Bgmn	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA	MGI:3702901
cx8	Igkc^tm1Bgmn/Igkc^tm1Bgmn Igl^tm2.1Bgmn/Igl^tm2.1Bgmn	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA	MGI:3702904

Genotype
MGI:3652818

hm1

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell number ( J:28868 , J:118712 )

• there are higher numbers of CD45R(B220)+ putative B cells in the Peyer's Patches compared to controls, despite reduced total cellularity (J:28868)

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to normal mice (J:118712)

abnormal Peyer's patch morphology ( J:28868 )

• in mutants PPs have a dramatically reduced cell content compared to controls

abnormal Peyer's patch germinal center morphology ( J:28868 )

• there are small but highly active germinal centers

abnormal humoral immune response ( J:28868 )

• after immunization with antigens which elicit a restricted response in normal mice, there is an elevated antibody titer but mice display no titer increase after secondary challenge

hematopoietic system

abnormal B cell number ( J:28868 , J:118712 )

• there are higher numbers of CD45R(B220)+ putative B cells in the Peyer's Patches compared to controls, despite reduced total cellularity (J:28868)

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to normal mice (J:118712)

Genotype
MGI:3806699

cx2

• Allelic Composition: Ighm^tm1Cgn/Ighm^tm1Cgn; Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm2.1Bgmn/Igl^tm2.1Bgmn
• Genetic Background: involves: 129

immune system

decreased IgG level ( J:130864 )

• IgG is not present in the sera

decreased IgM level ( J:130864 )

• IgM is not present in the sera

hematopoietic system

decreased IgG level ( J:130864 )

• IgG is not present in the sera

decreased IgM level ( J:130864 )

• IgM is not present in the sera

Genotype
MGI:3806697

cx3

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm2.1Bgmn/Igl^tm2.1Bgmn
• Genetic Background: involves: 129P2/OlaHsd

immune system

abnormal B cell differentiation ( J:130864 )

• B cell development is partially blocked at the small pre-B cell stage

• cells are released from the bone marrow as B220⁺CD21/CD35⁺ B cells

• there is also a small population (0.8%) of B cells expressing Igbeta

abnormal immunoglobulin heavy chain V(D)J recombination ( J:130864 )

• many heavy chain antibodies produced by B cells in these mice lack the Ch1 exon

abnormal plasma cell morphology ( J:130864 )

• plasma cells secrete heavy-chain only IgG

decreased IgG level ( J:130864 )

• reduced but detectable amounts of IgG antibody are found in the sera

• antibodies consist of heavy chain only homodimers

• antigen-specific IgG can be generated by several immunizations of OVA peptide

• these immunizations also result in increases to total IgG levels

decreased IgM level ( J:130864 )

• IgM is not present in the sera

hematopoietic system

abnormal B cell differentiation ( J:130864 )

• B cell development is partially blocked at the small pre-B cell stage

• cells are released from the bone marrow as B220⁺CD21/CD35⁺ B cells

• there is also a small population (0.8%) of B cells expressing Igbeta

abnormal immunoglobulin heavy chain V(D)J recombination ( J:130864 )

• many heavy chain antibodies produced by B cells in these mice lack the Ch1 exon

abnormal plasma cell morphology ( J:130864 )

• plasma cells secrete heavy-chain only IgG

decreased IgG level ( J:130864 )

• reduced but detectable amounts of IgG antibody are found in the sera

• antibodies consist of heavy chain only homodimers

• antigen-specific IgG can be generated by several immunizations of OVA peptide

• these immunizations also result in increases to total IgG levels

decreased IgM level ( J:130864 )

• IgM is not present in the sera

Genotype
MGI:3806698

cx4

• Allelic Composition: Ighm^tm3Bgmn/Ighm^tm3Bgmn; Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm2.1Bgmn/Igl^tm2.1Bgmn
• Genetic Background: involves: 129P2/OlaHsd * 129/Sv

hematopoietic system

abnormal B cell differentiation ( J:130864 )

• B cell development is partially blocked at the small pre-B cell stage but the expression of a heavy chain-only BCR overcomes this block

• there is a B cell population that makes up 8.4% of splenocytes that express Igbeta

decreased IgG level ( J:130864 )

• reduced but detectable amounts of IgG antibody are found in the sera

• antibodies consist of heavy chain only covalently linked homodimers

decreased IgM level ( J:130864 )

• IgM is present at reduced amounts in the sera

• IgM consist only of heavy chains that are non-covalently linked

immune system

abnormal B cell differentiation ( J:130864 )

• B cell development is partially blocked at the small pre-B cell stage but the expression of a heavy chain-only BCR overcomes this block

• there is a B cell population that makes up 8.4% of splenocytes that express Igbeta

decreased IgG level ( J:130864 )

• reduced but detectable amounts of IgG antibody are found in the sera

• antibodies consist of heavy chain only covalently linked homodimers

decreased IgM level ( J:130864 )

• IgM is present at reduced amounts in the sera

• IgM consist only of heavy chains that are non-covalently linked

Genotype
MGI:3702894

cx5

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm1.1Bgmn/Igl^tm1.1Bgmn
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

hematopoietic system

abnormal immature B cell morphology ( J:118712 )

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to Igk-C^tm1Bgmn mice

decreased B cell number ( J:118712 )

• IgM+ B cells are reduced in number in spleen and secondary lymph organs

absent B-1 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-1 cells

absent B-2 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-2 cells

absent B cells ( J:118712 )

• there is complete lack of mature B cells in spleen

spleen hypoplasia ( J:118712 )

• total cell numbers and weights are reduced by more than half compared to wild-type

immune system

abnormal immature B cell morphology ( J:118712 )

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to Igk-C^tm1Bgmn mice

decreased B cell number ( J:118712 )

• IgM+ B cells are reduced in number in spleen and secondary lymph organs

absent B-1 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-1 cells

absent B-2 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-2 cells

absent B cells ( J:118712 )

• there is complete lack of mature B cells in spleen

spleen hypoplasia ( J:118712 )

• total cell numbers and weights are reduced by more than half compared to wild-type

Genotype
MGI:3702900

cx6

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm1Bgmn/Igl^tm1Bgmn
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

hematopoietic system

abnormal immature B cell morphology ( J:118712 )

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to Igk-C^tm1Bgmn mice

decreased B cell number ( J:118712 )

• IgM+ B cells are reduced in number in spleen and secondary lymph organs

absent mature B cells ( J:118712 )

• there is complete lack of mature B cells in spleen

absent B-1 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-1 cells

absent B-2 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-2 cells

spleen hypoplasia ( J:118712 )

• total cell numbers and weights are reduced by more than half compared to wild-type

immune system

abnormal immature B cell morphology ( J:118712 )

• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 10⁶) in bone marrow is reduced by >50% compared to Igk-C^tm1Bgmn mice

decreased B cell number ( J:118712 )

• IgM+ B cells are reduced in number in spleen and secondary lymph organs

absent mature B cells ( J:118712 )

• there is complete lack of mature B cells in spleen

absent B-1 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-1 cells

absent B-2 B cells ( J:118712 )

• secondary lymphoid organs such as the peritoneum lack B-2 cells

spleen hypoplasia ( J:118712 )

• total cell numbers and weights are reduced by more than half compared to wild-type

Genotype
MGI:3702901

cx7

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm2Bgmn/Igl^tm2Bgmn
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

hematopoietic system

arrested B cell differentiation ( J:118712 )

• development is blocked at pre-B-II to immature B cell transition stage

absent B cells ( J:118712 )

• IgM+ B cells are undetectable in spleens of mutants

immune system

arrested B cell differentiation ( J:118712 )

• development is blocked at pre-B-II to immature B cell transition stage

absent B cells ( J:118712 )

• IgM+ B cells are undetectable in spleens of mutants

Genotype
MGI:3702904

cx8

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm2.1Bgmn/Igl^tm2.1Bgmn
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA

hematopoietic system

arrested B cell differentiation ( J:118712 )

• development is blocked at pre-B-II to immature B cell transition stage

absent B cells ( J:118712 )

• IgM+ B cells are undetectable in spleens of mutants

immune system

arrested B cell differentiation ( J:118712 )

• development is blocked at pre-B-II to immature B cell transition stage

absent B cells ( J:118712 )

• IgM+ B cells are undetectable in spleens of mutants