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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Clocktm1.1Rep
targeted mutation 1.1, Steven M Reppert
MGI:3652400
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Clocktm1.1Rep/Clocktm1.1Rep involves: 129S4/SvJae * C57BL/6J MGI:3652547


Genotype
MGI:3652547
hm1
Allelic
Composition
Clocktm1.1Rep/Clocktm1.1Rep
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clocktm1.1Rep mutation (1 available); any Clock mutation (101 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• after light-dark entrainment for several weeks (L/D - 12/12 hours) followed by an extension of the light period by 4 hours, wild-type mice and heterozygotes exhibit a phase delay of ~1.6-1.9 hours whereas mutants don't show any delay
• mutants become active ~ 2 hours before lights-off (start of dark cycle) while wild-type mice show activity at onset of dark period
• after LD entrainment for 3 weeks, exposure to a light pulse late in the dark phase followed by release into total darkness results in a phase advance of 6.8 hours compared to 1.8-2 hours exhibited by wild-type and heterozygotes in the same paradigm





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory