About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Mef2c-cre)2Blk
transgene insertion 2, Brian L Black
MGI:3639735
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tg(Mef2c-cre)2Blk/0
B6.Cg-Kmt2dtm1.1Kaig Tg(Mef2c-cre)2Blk MGI:5780096
cn2
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(Mef2c-cre)2Blk/0
involves: 129 * C57BL/6 MGI:5538608
cn3
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Tg(Mef2c-cre)2Blk/?
involves: 129P2/OlaHsd MGI:5707469
cn4
Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?
Tg(Mef2c-cre)2Blk/?
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:4941612
cn5
Shhtm1Chg/Shhtm2Chg
Tg(Mef2c-cre)2Blk/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:4843920
cn6
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor MGI:4941218
cn7
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor MGI:4941214
cn8
Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
involves: 129S4/SvJaeSor * C57BL/6 MGI:4941217
cn9
Fgf8tm2Moon/Fgf8tm1Mrc
Tg(Mef2c-cre)2Blk/0
Not Specified MGI:3639738


Genotype
MGI:5780096
cn1
Allelic
Composition
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tg(Mef2c-cre)2Blk/0
Genetic
Background
B6.Cg-Kmt2dtm1.1Kaig Tg(Mef2c-cre)2Blk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2dtm1.1Kaig mutation (1 available); any Kmt2d mutation (110 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• while present at E11.5, mice die by E13.5

cardiovascular system




Genotype
MGI:5538608
cn2
Allelic
Composition
Tbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3tm3.1Moon mutation (0 available); any Tbx3 mutation (15 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• atrial arrhythmia
• in most mice from E12.5 to E13.5




Genotype
MGI:5707469
cn3
Allelic
Composition
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Tg(Mef2c-cre)2Blk/?
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hic2Gt(E225A08)1.1Wrst mutation (0 available); any Hic2 mutation (254 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no embryonic lethality

cardiovascular system
N
• no heart defects or external phenotype




Genotype
MGI:4941612
cn4
Allelic
Composition
Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?
Tg(Mef2c-cre)2Blk/?
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm2(tetO-Bmp4,lacZ)Jfm mutation (0 available); any Bmp4 mutation (17 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (3 available); any Gt(ROSA)26Sor mutation (510 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in the right ventricle and out flow tract

cardiovascular system
• in the right ventricle and out flow tract
• thickening of the myocardium
• thickening of the myocardium




Genotype
MGI:4843920
cn5
Allelic
Composition
Shhtm1Chg/Shhtm2Chg
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shhtm1Chg mutation (1 available); any Shh mutation (22 available)
Shhtm2Chg mutation (0 available); any Shh mutation (22 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal outflow tracts
• at E18.5, 4 of 16 mice exhibit abnormal arch-artery patterning compared with wild-type mice
• in 14 of 16 mice
• however, mice exhibit normal outflow tract length with no increase in apoptosis




Genotype
MGI:4941218
cn6
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (17 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• defect in outflow tract remodeling at E12.5 due to a deficiency in proximal outflow tract mesenchyme
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• at E14.5 and E18.5, the alignment of the aorta and pulmonary trunk is abnormal




Genotype
MGI:4941214
cn7
Allelic
Composition
Bmp2tm1Jfm/Bmp2tm1Jfm
Bmp4tm1Jfm/Bmp4tm1Jfm
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Jfm mutation (1 available); any Bmp2 mutation (4 available)
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (17 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• dramatic reduction in the amount of sarcomeric myosin

homeostasis/metabolism




Genotype
MGI:4941217
cn8
Allelic
Composition
Bmp4tm1Jfm/Bmp4tm1Jfm
Mirc1tm1.2Tyj/Mirc1tm1.2Tyj
Tg(Mef2c-cre)2Blk/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Jfm mutation (1 available); any Bmp4 mutation (17 available)
Mirc1tm1.2Tyj mutation (1 available); any Mirc1 mutation (6 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• proximal outflow tract mesenchyme deficiency is more severe than in mutant mice wild-type for Mir17-92
• failure of fusion between proximal mesenchyme and outflow tract septum
• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• deficiency is more severe than in mutant mice wild-type for Mir17-92




Genotype
MGI:3639738
cn9
Allelic
Composition
Fgf8tm2Moon/Fgf8tm1Mrc
Tg(Mef2c-cre)2Blk/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1Mrc mutation (0 available); any Fgf8 mutation (11 available)
Fgf8tm2Moon mutation (0 available); any Fgf8 mutation (11 available)
Tg(Mef2c-cre)2Blk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 25% of mutants have TGA and double outlet right ventricle
• 25% of mutants have TGA and double outlet right ventricle





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory