All Phenotypes Tg(Pou4f3-cre)1Devet MGI Mouse

impaired swimming ( J:109453 )

• at 3 and 6 months, mutants are unable to swim with their heads above water

circling ( J:109453 )

• at 3 and 6 months, mutants display moderate circling behavior

abnormal organ of Corti supporting cell proliferation ( J:109453 )

• at P17, cochlear supporting cells are proliferating but in wild-type no proliferation is occurring at this age

abnormal organ of Corti morphology ( J:109453 )

• in the basal turn, the tunnel of corti has collapsed in 6-week old animals

abnormal cochlear hair cell morphology ( J:109453 )

• at P1 cochlear hair cells are still undergoing proliferation but in wild-type no proliferation is occurring at this age

increased cochlear inner hair cell number ( J:109453 )

• more inner hair cells than wild-type

abnormal cochlear outer hair cell morphology ( J:109453 )

• many outer hair cells lack bundles; atypical bundles including ring-shaped bundles and 2 bundles within one hair cell are occasionally observed

increased cochlear outer hair cell number ( J:109453 )

• more outer hair cells than wild-type

cochlear hair cell degeneration ( J:109453 )

• total hair cell loss by 3 months of age

cochlear outer hair cell degeneration ( J:109453 )

• from P6 to P17, there is apoptosis in the outer hair cell region of the organ of corti

abnormal vestibular hair cell morphology ( J:109453 )

• at P17, utrical hair cells are proliferating but in wild-type no proliferation is occurring at this age

vestibular hair cell degeneration ( J:109453 )

• numbers of vestibular hair cells decrease from early postnatal to adult stages

• at P6, there are three to four layers of hair cells in the utricle, but at 3 months, only 1-2 layers remain

• by 6 months, there are thin and disorganized hair bundles in most hair cells in the utricles

deafness ( J:109453 )

• mice are profoundly deaf by 3 months of age when all hair cells are lost

abnormal vestibular system physiology ( J:109453 )

• at 3 and 6 months, mutants display moderate circling behavior and can not swim with their heads above water

• at 6 months, partial vestibular function remains in mutants with hair cell and behavioral abnormalities