Analysis Tools
neoplasm
|
• mice develop leukemias, fibrosarcomas, granuloma and adenomas; these are rarely seen in Trp53tm1Tyj homozygous mice
|
|
• mice are cancer prone but develop tumors in a wide spectrum of tissues, with a delayed onset compared with Trp53-null mice which develop thymic lymphomas primarily within 6 months of age
|
hematopoietic system
|
• thymocytes are essentially resistant to Trp53-mediated apoptosis
|
|
• proliferation of thymocytes after stimulation with PMA or Ionomycin is slower than Trp53tm1Tyj cells at the later time point, but similar to wild-type at the earlier time point
|
immune system
|
• thymocytes are essentially resistant to Trp53-mediated apoptosis
|
|
• proliferation of thymocytes after stimulation with PMA or Ionomycin is slower than Trp53tm1Tyj cells at the later time point, but similar to wild-type at the earlier time point
|
cellular
|
• thymocytes are essentially resistant to Trp53-mediated apoptosis
|
|
• proliferation of thymocytes after stimulation with PMA or Ionomycin is slower than Trp53tm1Tyj cells at the later time point, but similar to wild-type at the earlier time point
|
