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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdrtm2.1Jrt
targeted mutation 2.1, Janet Rossant
MGI:3629041
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6 MGI:5705503
cn2
 		Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129S1/Sv * 129X1/SvJ MGI:5705500
cn3
 		Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Cdh5-cre/ERT2)#Ykub/0 		involves: 129S1/Sv * 129X1/SvJ MGI:5705501
cn4
 		Kdrtm1Ykub/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129S1/Sv * 129X1/SvJ MGI:5705499
cx5
 		Angpt1tm1.2Seq/Angpt1tm1.2Seq
Kdrtm2.1Jrt/Kdr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5140325


Genotype
MGI:5705503
cn1
Allelic
Composition		 Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.1Pdc mutation (1 available); any Dnm1 mutation (40 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (99 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (71 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:217533 )
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected

vision/eye
abnormal retina vasculature morphology ( J:217533 )
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected




Genotype
MGI:5705500
cn2
Allelic
Composition		 Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (71 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:217533 )
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice
• misdirected vascular growth
• at P9, deep and intermediate plexuses have already formed unlike in control mice
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice
• however, no additional angiogenesis is observed

vision/eye
vision/eye phenotype ( J:217533 )
N
• retinas exhibit normal neuronal thickness, morphology, proliferation and survival and vertical sprouts extend between normal ganglion cells
abnormal retina vasculature morphology ( J:217533 )
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice
• misdirected vascular growth
• at P9, deep and intermediate plexuses have already formed unlike in control mice
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice
• however, no additional angiogenesis is observed




Genotype
MGI:5705501
cn3
Allelic
Composition		 Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Cdh5-cre/ERT2)#Ykub/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (71 available)
Tg(Cdh5-cre/ERT2)#Ykub mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:217533 )
• impaired radial vascular growth
• however, no misdirected sprouting is observed in the neuroretina

vision/eye
abnormal retina vasculature morphology ( J:217533 )
• impaired radial vascular growth
• however, no misdirected sprouting is observed in the neuroretina




Genotype
MGI:5705499
cn4
Allelic
Composition		 Kdrtm1Ykub/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Ykub mutation (0 available); any Kdr mutation (71 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (71 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:217533 )
N
• no misdirected angiogenesis is detected in the retina

vision/eye
vision/eye phenotype ( J:217533 )
N
• no misdirected angiogenesis is detected in the retina




Genotype
MGI:5140325
cx5
Allelic
Composition		 Angpt1tm1.2Seq/Angpt1tm1.2Seq
Kdrtm2.1Jrt/Kdr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angpt1tm1.2Seq mutation (0 available); any Angpt1 mutation (35 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Loss of trabeculations in the heart of E9.5 and E10.5 Angpt1tm1.2Seq/Angpt1tm1.2Seq Kdrtm2.1Jrt/Kdr+ embryos

mortality/aging

cardiovascular system
abnormal brain vasculature morphology ( J:174022 )
• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice
abnormal vascular development ( J:174022 )
• at E10.5, mice exhibit vascular defects with fusion of large diameter vessels and absence of patterning compared with wild-type mice
• however, pericyte coverage is normal
abnormal heart development ( J:174022 )
• at E 9.5, mice exhibit heart defects and loss of heart trabeculation unlike wild-type mice

embryo

nervous system
abnormal brain vasculature morphology ( J:174022 )
• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice

growth/size/body
decreased embryo size ( J:174022 )
• at E10.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory