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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2i7
i7 variant
MGI:3628766
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2i7/H2i7 NOD.Cg-H2i7 MGI:3628775
ht2
H2i7/H2g7 (NOD x NOD.Cg-H2i7)F1 MGI:3628793
ht3
H2i7/H2g7 NOD.Cg-H2i7 MGI:3628791


Genotype
MGI:3628775
hm1
Allelic
Composition
H2i7/H2i7
Genetic
Background
NOD.Cg-H2i7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2i7 mutation (1 available); any H2 mutation (274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

homeostasis/metabolism
• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

immune system
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates
• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation




Genotype
MGI:3628793
ht2
Allelic
Composition
H2i7/H2g7
Genetic
Background
(NOD x NOD.Cg-H2i7)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (22 available); any H2 mutation (274 available)
H2i7 mutation (1 available); any H2 mutation (274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis

immune system
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis




Genotype
MGI:3628791
ht3
Allelic
Composition
H2i7/H2g7
Genetic
Background
NOD.Cg-H2i7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (22 available); any H2 mutation (274 available)
H2i7 mutation (1 available); any H2 mutation (274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory