Phenotypes associated with this allele

• Allele Symbol: H2^h4
• Allele Name: h4 variant
• Allele ID: MGI:3628615
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2^h4/H2^h4	NOD.Cg-H2^h4	MGI:3628646
ht2	H2^h4/H2^g7	NOD.Cg-H2^h4	MGI:3628787

Genotype
MGI:3628646

hm1

• Allelic Composition: H2^h4/H2^h4
• Genetic Background: NOD.Cg-H2^h4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:14178 )

• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections

endocrine/exocrine glands

thyroid gland inflammation ( J:54563 )

• without NaI supplementation, many H2^h4 mice develop lesions, but lesions are rarely observed before 6 months of age

• almost 100% of mice develop thyroiditis 6-8 weeks after receiving NaI in water beginning at 8 weeks of age; lesions are observed as early as 2 weeks after the start of NaI supplementation

• lesion severity peaks at about 8 weeks and remains unchanged until 23 weeks; response is chronic if NaI treatment is stopped after 7 weeks

• males develop more severe lesions more frequently than females

• with CD4+ T cell depletion prior to autoantibody production, mice do not develop SAT; depletion of CD8+ T cells has little effect on severity of lesions

insulitis ( J:14178 )

• female mice develop insulitis between 8 and 10 months of age

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 8-10 months of age; mice between 5 and 13 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

immune system

thyroid gland inflammation ( J:54563 )

• almost 100% of mice develop thyroiditis 6-8 weeks after receiving NaI in water beginning at 8 weeks of age; lesions are observed as early as 2 weeks after the start of NaI supplementation

• without NaI supplementation, many H2^h4 mice develop lesions, but lesions are rarely observed before 6 months of age

• lesion severity peaks at about 8 weeks and remains unchanged until 23 weeks; response is chronic if NaI treatment is stopped after 7 weeks

• males develop more severe lesions more frequently than females

• with CD4+ T cell depletion prior to autoantibody production, mice do not develop SAT; depletion of CD8+ T cells has little effect on severity of lesions

insulitis ( J:14178 )

• female mice develop insulitis between 8 and 10 months of age

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 8-10 months of age; mice between 5 and 13 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

abnormal cytokine secretion ( J:54563 )

• mice which do not have thyroiditis express barely detectable levels of cytokines (Ifng, Il4, 5, 10, 13 and Tnfa); with development of lesions about 4-6 weeks after start of NaI treatment, expression of all cytokines except Tgfb increases

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no female mice homozygous for the haplotype develop diabetes spontaneously

Genotype
MGI:3628787

ht2

• Allelic Composition: H2^h4/H2^g7
• Genetic Background: NOD.Cg-H2^h4

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months