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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(RARE-Hspa1b/lacZ)12Jrt
transgene insertion 12, Janet Rossant
MGI:3625954
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi
Tg(Amh-cre)8815Reb/0
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Stra8-icre)1Reb/0
involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL MGI:5475537
cn2
Rdh7tm1c(KOMP)Wtsi/Rdh7tm1c(KOMP)Wtsi
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Vil1-cre)997Gum/0
involves: C57BL/6J * C57BL/6N * CD-1 * SJL MGI:6362927
cx3
Dhrs3tm1Lex/Dhrs3tm1Lex
Tg(RARE-Hspa1b/lacZ)12Jrt/0
involves: 129S5/SvEvBrd * C57BL/6 * CD-1 MGI:5553307
tg4
Tg(RARE-Hspa1b/lacZ)12Jrt/0 involves: CD-1 MGI:3795698


Genotype
MGI:5475537
cn1
Allelic
Composition
Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi
Tg(Amh-cre)8815Reb/0
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Stra8-icre)1Reb/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh10tm1c(KOMP)Wtsi mutation (0 available); any Rdh10 mutation (16 available)
Tg(Amh-cre)8815Reb mutation (2 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
Tg(Stra8-icre)1Reb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

endocrine/exocrine glands




Genotype
MGI:6362927
cn2
Allelic
Composition
Rdh7tm1c(KOMP)Wtsi/Rdh7tm1c(KOMP)Wtsi
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh7tm1c(KOMP)Wtsi mutation (0 available); any Rdh7 mutation (13 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal numbers of TH17 and T regulatory cells in the small intestine and colon
• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria
• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal
• enhanced resistance to colonization by gut pathogens (C. rodentium and S. Typhimurium) with reduced colony forming units in the feces and spleen
• however, IL22 supplementation reverses resistance

hematopoietic system
• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria
• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal




Genotype
MGI:5553307
cx3
Allelic
Composition
Dhrs3tm1Lex/Dhrs3tm1Lex
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhrs3tm1Lex mutation (3 available); any Dhrs3 mutation (16 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mice exhibit severe developmental abnormalities with increased in transgene activity




Genotype
MGI:3795698
tg4
Allelic
Composition
Tg(RARE-Hspa1b/lacZ)12Jrt/0
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RARE-Hspa1b/lacZ)12Jrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• mice were used for expression analysis only





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory