Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh10tm1c(KOMP)Wtsi mutation
(0 available);
any
Rdh10 mutation
(20 available)
Tg(Amh-cre)8815Reb mutation
(2 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation
(2 available)
Tg(Stra8-icre)1Reb mutation
(2 available)
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reproductive system
endocrine/exocrine glands
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh7tm1c(KOMP)Wtsi mutation
(0 available);
any
Rdh7 mutation
(23 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation
(2 available)
Tg(Vil1-cre)997Gum mutation
(2 available)
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immune system
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N |
• mice exhibit normal numbers of TH17 and T regulatory cells in the small intestine and colon
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• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria
• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal
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• enhanced resistance to colonization by gut pathogens (C. rodentium and S. Typhimurium) with reduced colony forming units in the feces and spleen
• however, IL22 supplementation reverses resistance
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hematopoietic system
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• reduced NCR+ IL22-producing RORgammat+ innate lymphoid cells (ILC3s) in the small intestinal lamina propria
• however, the number of NCR- ILC3s and lymphoid tissue inducer (LTi) cells are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhrs3tm1Lex mutation
(3 available);
any
Dhrs3 mutation
(25 available)
Tg(RARE-Hspa1b/lacZ)12Jrt mutation
(2 available)
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embryo
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• mice exhibit severe developmental abnormalities with increased in transgene activity
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Analysis Tools