Mouse Genome Informatics
cn1
    Cd19tm1(cre)Cgn/Cd19+
Tnftm2.1Gkl/Tnftm2.1Gkl

involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• unlike mice with recombination in T cells, mice do not develop inflammatory bowel disease (J:108572)


Mouse Genome Informatics
cn2
    Tnftm2.1Gkl/Tnf+
Lyz2tm1(cre)Ifo/Lyz2+

involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size/body
• past 4 months of age, mice display weight loss


Mouse Genome Informatics
cn3
    Tnftm2.1Gkl/Tnftm2.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+

involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size/body
• past 4 months of age, mice display weight loss which is more severe than in mice heterozygous for both alleles


Mouse Genome Informatics
cn4
    Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Fabp1-cre)1Jig/0

involves: 129S/SvEv * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
digestive/alimentary system
• prominent villous distortion characterized by widening and decreased number of villi
• disruption of the mucosal architecture with prominent villous distortion characterized by widening and decreased number of villi
• increase in numbers of activated CD4+ cells within their intestinal mucosa
• low-grade inflammatory cell infiltration with both active and chronic components is seen in the colon
• chronic small intestinal inflammation
• mice exhibit severe inflammatory changes in the ilea, including dense infiltration of the lamina propria by acute (polymorphonuclear), but mainly chronic (lymphocytes, macrophages), inflammatory cells
• however, no inflammation is seen in other parts of the small intestine, including the jejunum , and mice do not develop inflammatory arthritis

immune system
• low-grade inflammatory cell infiltration with both active and chronic components is seen in the colon
• chronic small intestinal inflammation
• mice exhibit severe inflammatory changes in the ilea, including dense infiltration of the lamina propria by acute (polymorphonuclear), but mainly chronic (lymphocytes, macrophages), inflammatory cells
• however, no inflammation is seen in other parts of the small intestine, including the jejunum , and mice do not develop inflammatory arthritis

homeostasis/metabolism


Mouse Genome Informatics
cn5
    Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Lck-cre)I57Jxm/0

involves: 129S/SvEv * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes

digestive/alimentary system
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes