About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnftm2.1Gkl
targeted mutation 2.1, George Kollias
MGI:3625620
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cd19tm1(cre)Cgn/Cd19+
Tnftm2.1Gkl/Tnftm2.1Gkl
involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J MGI:3629600
cn2
Tnftm2.1Gkl/Tnf+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J MGI:3629610
cn3
Tnftm2.1Gkl/Tnftm2.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3629596
cn4
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Fabp1-cre)1Jig/0
involves: 129S/SvEv * FVB/N MGI:5558947
cn5
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Lck-cre)I57Jxm/0
involves: 129S/SvEv * ICR MGI:3629599


Genotype
MGI:3629600
cn1
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Tnftm2.1Gkl/Tnftm2.1Gkl
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (6 available); any Cd19 mutation (13 available)
Tnftm2.1Gkl mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike mice with recombination in T cells, mice do not develop inflammatory bowel disease




Genotype
MGI:3629610
cn2
Allelic
Composition
Tnftm2.1Gkl/Tnf+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (11 available)
Tnftm2.1Gkl mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• past 4 months of age, mice display weight loss




Genotype
MGI:3629596
cn3
Allelic
Composition
Tnftm2.1Gkl/Tnftm2.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (11 available)
Tnftm2.1Gkl mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• past 4 months of age, mice display weight loss which is more severe than in mice heterozygous for both alleles




Genotype
MGI:5558947
cn4
Allelic
Composition
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Fabp1-cre)1Jig/0
Genetic
Background
involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Fabp1-cre)1Jig mutation (2 available)
Tnftm2.1Gkl mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• disruption of the mucosal architecture with prominent villous distortion characterized by widening and decreased number of villi
• increase in numbers of activated CD4+ cells within their intestinal mucosa
• prominent villous distortion characterized by widening and decreased number of villi
• low-grade inflammatory cell infiltration with both active and chronic components is seen in the colon
• chronic small intestinal inflammation
• mice exhibit severe inflammatory changes in the ilea, including dense infiltration of the lamina propria by acute (polymorphonuclear), but mainly chronic (lymphocytes, macrophages), inflammatory cells
• however, no inflammation is seen in other parts of the small intestine, including the jejunum , and mice do not develop inflammatory arthritis

immune system
• low-grade inflammatory cell infiltration with both active and chronic components is seen in the colon
• chronic small intestinal inflammation
• mice exhibit severe inflammatory changes in the ilea, including dense infiltration of the lamina propria by acute (polymorphonuclear), but mainly chronic (lymphocytes, macrophages), inflammatory cells
• however, no inflammation is seen in other parts of the small intestine, including the jejunum , and mice do not develop inflammatory arthritis

homeostasis/metabolism




Genotype
MGI:3629599
cn5
Allelic
Composition
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Lck-cre)I57Jxm/0
Genetic
Background
involves: 129S/SvEv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (0 available)
Tnftm2.1Gkl mutation (0 available); any Tnf mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes

digestive/alimentary system
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory