Mouse Genome Informatics
cn1
    Cd19tm1(cre)Cgn/Cd19+
Tnftm2.1Gkl/Tnftm2.1Gkl

involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• unlike mice with recombination in T cells, mice do not develop inflammatory bowel disease (J:108572)


Mouse Genome Informatics
cn2
    Tnftm2.1Gkl/Tnf+
Lyz2tm1(cre)Ifo/Lyz2+

involves: 129P2/OlaHsd * 129S/SvEv * 129S6/SvEvTac * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• past 4 months of age, mice display weight loss


Mouse Genome Informatics
cn3
    Tnftm2.1Gkl/Tnftm2.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+

involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• past 4 months of age, mice display weight loss which is more severe than in mice heterozygous for both alleles


Mouse Genome Informatics
cn4
    Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Lck-cre)I57Jxm/0

involves: 129S/SvEv * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes

digestive/alimentary system
• mice develop mice develop inflammatory bowel disease past 5 months of age with reduced severity compared to Tnftm2.1Gkl, Lyzstm1(cre)Ifo double homozygotes or Tnftm2Gkl heterozygotes