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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Aqp2tm1Nlsn
targeted mutation 1, Soren Nielsen
MGI:3624696
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Aqp2tm1Nlsn/Aqp2tm1Nlsn
Tg(Hoxb7-cre)13Amc/0
involves: 129/Sv * C57BL/6 MGI:3626345


Genotype
MGI:3626345
cn1
Allelic
Composition
Aqp2tm1Nlsn/Aqp2tm1Nlsn
Tg(Hoxb7-cre)13Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp2tm1Nlsn mutation (0 available); any Aqp2 mutation (12 available)
Tg(Hoxb7-cre)13Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
• osmolality is only 170 +/- 19 milliosmoles/kg of water compared to 1630 +/- 135 milliosmoles/kg of water for wild-type mice
• water deprivation does not increase urine osmolality
• variable progressive papillary atrophy in those that survive past weaning
• variable progressive hydronephrosis in those that survive past weaning
• about a 10-fold increase in urine output
• water deprivation results in only a marginal decrease in urine output

homeostasis/metabolism
• osmolality is only 170 +/- 19 milliosmoles/kg of water compared to 1630 +/- 135 milliosmoles/kg of water for wild-type mice
• water deprivation does not increase urine osmolality





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory