All Phenotypes Hipk2<tm1Hko> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hipk2^tm1Hko
targeted mutation 1, Haruhiko Koseki
MGI:3624127

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hipk2^tm1Hko/Hipk2^tm1Hko	involves: C57BL/6	MGI:3624996
cx2	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2^tm1Hko Trp53^tm2Mok/Trp53⁺	involves: 129S/SvEv * C57BL/6	MGI:3625003
cx3	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2^tm1Hko	involves: C57BL/6	MGI:3624999
cx4	Hipk1^tm1Hko/Hipk1⁺ Hipk2^tm1Hko/Hipk2^tm1Hko	involves: C57BL/6	MGI:3625000
cx5	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2⁺	involves: C57BL/6	MGI:3625001

Allelic Composition	Hipk2^tm1Hko/Hipk2^tm1Hko
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk2^tm1Hko mutation (0 available); any Hipk2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:106931 )

• embryonic fibroblasts from null mice are slightly resistant to UV radiation compared to wild-type

• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

embryo

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

Allelic Composition	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2^tm1Hko Trp53^tm2Mok/Trp53⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1^tm1Hko mutation (0 available); any Hipk1 mutation (61 available)
Hipk2^tm1Hko mutation (0 available); any Hipk2 mutation (53 available)
Trp53^tm2Mok mutation (2 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

exencephaly ( J:106931 )

• four triple mutants were found to be exencephalic, whereas none were found to be wild-type for Trp53

Allelic Composition	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2^tm1Hko
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis ( J:106931 )

growth/size/body

embryonic growth retardation ( J:106931 )

• at E9.5, 14 of 17 live double homozygotes are smaller and developmentally delayed compared to Hipk1^tm1Kho homozygous or Hipk1^tm1Kho/Hipk1^tm1Kho Hipk2+/+ embryos

cellular

increased apoptosis ( J:106931 )

• significantly more apoptotic cells are observed in the condensing trigeminal and facioacoustic neural crest cells, as well as in the sclerotomal compartment, compared to Hipk1-null, Hipk2-wild-type mutants

decreased cell proliferation ( J:106931 )

• at E9.5, the frequency of mitotic cells in the cranial and caudal regions of the neural tube of double homozygotes is reduced to 45% and 29% compared to Hipk1-null, Hipk2 wild-type homozygotes

• proliferation of the cephalic mesoderm is reduced to 43% of that in Hipk1-null, Hipk2-wild-type double mutants

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

exencephaly ( J:106931 )

• half of the homozygous embryos surviving to beyond E9.5 exhibit exencephaly

vision/eye

abnormal lens vesicle development ( J:106931 )

• in mutants lens vesicle formation fails with disorientation of the optic cups and fusion of the dorsal root ganglia

embryo

embryonic growth retardation ( J:106931 )

• at E9.5, 14 of 17 live double homozygotes are smaller and developmentally delayed compared to Hipk1^tm1Kho homozygous or Hipk1^tm1Kho/Hipk1^tm1Kho Hipk2+/+ embryos

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

Allelic Composition	Hipk1^tm1Hko/Hipk1⁺ Hipk2^tm1Hko/Hipk2^tm1Hko
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:106931 )

• about half of the mutants are lost during gestation, compared to the predicted number

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:106931 )

• embryonic fibroblasts from mutant mice are more resistant to UV radiation compared to single Hipk1 or Hipk2-null mice

• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

embryo

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

Allelic Composition	Hipk1^tm1Hko/Hipk1^tm1Hko Hipk2^tm1Hko/Hipk2⁺
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

exencephaly ( J:106931 )

• a small number of these mutants exhibit exencephaly

embryo

abnormal neural tube morphology ( J:106931 )

• neural tube defects occur more frequently in female compound mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23