Phenotypes associated with this allele
Allelic
Composition |
Recktm1Ito/Recktm1Ito
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Genetic
Background |
either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Recktm1Ito mutation
(1 available);
any
Reck mutation
(46 available)
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mortality/aging
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• 2/3 die around E10.5 and none survive beyond E11.5
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growth/size/body
embryo
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• although vascular networks form in the yolk sac, their morphology resembles primitive vascular plexuses, suggesting defects in blood vessel maturation
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cardiovascular system
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• vascular endothelial cells do not form tight and thin tubular structures
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• although vascular networks form in the embryo, their morphology resembles primitive vascular plexuses, suggesting defects in blood vessel maturation
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• frequently exhibit abdominal hemorrhage
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cellular
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• exhibit almost complete loss of collagen fibrils and a discontinuous basal lamina surrounding the neural tube and blood vessels
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Recktm1Ito mutation
(1 available);
any
Reck mutation
(46 available)
|
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cardiovascular system
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• at E10.5, the series of periodically spaced contact zones in the pernineural vascular basement membrane compared to in wild-type mice
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• at E10.5, mice exhibit abdominal hemorrhage unlike wild-type mice
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embryo
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• yolk sacs exhibit irregularly shaped sprouts or branches instead of the numerous small holes in the arterial domain observed in wild-type mice
• in the lateral regions, arteries are winding and variable in thickness compared to in wild-type yolk sac
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Recktm1.1Noda mutation
(0 available);
any
Reck mutation
(46 available)
Recktm1Ito mutation
(1 available);
any
Reck mutation
(46 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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mortality/aging
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• mice treated with tamoxifen at E11 die after E15.5
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cardiovascular system
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• at E15.5, blood vessels in tamoxifen-treated mice are large and irregularly shaped compared to in wild-type mice
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• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice
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• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice
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• at E15.5, blood vessels in tamoxifen-treated mice are large and irregularly shaped compared to in wild-type mice
• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice
• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice
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• in tamoxifen-treated mice
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• at E15.5 in tamoxifen-treated mice
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growth/size/body
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• at E15.5 in tamoxifen-treated mice
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liver/biliary system
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• the blood vessels in the livers of tamoxifen-treated mice exhibit larger luminal spaces than in wild-type mice
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nervous system
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• brain vasculature in tamoxifen-treated mice is disorganized and interrupted by large spaces and cavities unlike in wild-type mice
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integument
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• at E15.5 in tamoxifen-treated mice
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mortality/aging
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• 2/3 die by E11 and none survive beyond E11.5, however exhibit partial rescue of the phenotypes seen in single Reck homozygotes such as increased body size and tissue integrity
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Analysis Tools