All Phenotypes Adipoq<tm1Pesch> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adipoq^tm1Pesch
targeted mutation 1, Philipp E Scherer
MGI:3623488

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adipoq^tm1Pesch/Adipoq^tm1Pesch	B6.129S7-Adipoq^tm1Pesch	MGI:6106865
hm2	Adipoq^tm1Pesch/Adipoq^tm1Pesch	involves: 129S7/SvEvBrd	MGI:3623746
hm3	Adipoq^tm1Pesch/Adipoq^tm1Pesch	involves: C57BL/6	MGI:5620310
cx4	Adipoq^tm1Pesch/Adipoq^tm1Pesch Lep^ob/Lep^ob	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3623747

Allelic Composition	Adipoq^tm1Pesch/Adipoq^tm1Pesch
Genetic Background	B6.129S7-Adipoq^tm1Pesch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Pesch mutation (0 available); any Adipoq mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:210480 )

• cold-exposed mice exhibit higher core body temperature than wild-type mice

• cold-exposed mice exhibit a greater increase in brown adipocyte-like regions in inguinal fat compared with wild-type mice

• however, resistance to hypothermia is abolished when the interscapular brown adipose tissue is removed

increased core body temperature ( J:210480 )

• when housed at room temperature or cold exposed

• however, adenoviral expression of adiponectin abolishes the increased body temperature

increased energy expenditure ( J:210480 )

• at the onset of the dark phase

increased oxygen consumption ( J:210480 )

• in the presence of the lipid substrate palmitoyl carnitine

• however, adenoviral expression of adiponectin reduces the rate

adipose tissue

abnormal inguinal fat pad morphology ( J:210480 )

• cold-exposed mice exhibit a greater increase in brown adipocyte-like regions in inguinal fat compared with wild-type mice

cellular

abnormal respiratory electron transport chain ( J:210480 )

• reduced mitochondrial respiration without altering mitochondrial biogenesis

Allelic Composition	Adipoq^tm1Pesch/Adipoq^tm1Pesch
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Pesch mutation (0 available); any Adipoq mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal gluconeogenesis ( J:107486 )

• impaired suppression of hepatic glucose production by glucose infusion

impaired glucose tolerance ( J:107486 )

• attenuated glucose tolerance when placed on a high fat diet for 10 weeks

Allelic Composition	Adipoq^tm1Pesch/Adipoq^tm1Pesch
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Pesch mutation (0 available); any Adipoq mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

maternal effect ( J:219264 )

• lactation defects result in smaller pups and pups with dorsal hair alopecia (hyperplasia and follicular cysts formation) beginning from postnatal day 20-25 but recover 1 week after weaning

Allelic Composition	Adipoq^tm1Pesch/Adipoq^tm1Pesch Lep^ob/Lep^ob
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Pesch mutation (0 available); any Adipoq mutation (40 available)
Lep^ob mutation (5 available); any Lep mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:107486 )

• glucose intolerance which is resistant to treatment with rosiglitazone

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