All Phenotypes Abcc2<tm1Ahs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Abcc2^tm1Ahs
targeted mutation 1, Alfred H Schinkel
MGI:3621934

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc2^tm1Ahs/Abcc2^tm1Ahs	B6.129P2(FVB)-Abcc2^tm1Ahs	MGI:5609257
hm2	Abcc2^tm1Ahs/Abcc2^tm1Ahs	FVB.129P2-Abcc2^tm1Ahs	MGI:3622122
hm3	Abcc2^tm1Ahs/Abcc2^tm1Ahs	involves: 129P2/OlaHsd * FVB	MGI:3622121
cx4	Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Abcc2^tm1Ahs/Abcc2^tm1Ahs	FVB.129P2-Abcb1b^tm1Bor Abcb1a^tm1Bor Abcc2^tm1Ahs	MGI:3622124

Allelic Composition	Abcc2^tm1Ahs/Abcc2^tm1Ahs
Genetic Background	B6.129P2(FVB)-Abcc2^tm1Ahs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc2^tm1Ahs mutation (0 available); any Abcc2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating bilirubin level ( J:208127 )

increased physiological sensitivity to xenobiotic ( J:208127 )

• display greater increases in BUN 4 days after cisplatin exposure and a mild increase in alanine aminotransferase activity is seen only in mutant mice and not wild-type mice after cisplatin treatment

• cisplatin induced proximal tubule degeneration and necrosis is more severe compared to wild-type controls at 4 days post exposure

• kidney concentrations of platinum are elevated above wild-type levels at 24 and 48 hours and liver levels are elevated through 72 hours after cisplatin exposure

Allelic Composition	Abcc2^tm1Ahs/Abcc2^tm1Ahs
Genetic Background	FVB.129P2-Abcc2^tm1Ahs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc2^tm1Ahs mutation (0 available); any Abcc2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating bilirubin level ( J:216646 )

bilirubinuria ( J:216646 )

abnormal xenobiotic pharmacokinetics ( J:107822 )

• bilary excretion of doxorubicin is reduced by about 50%

renal/urinary system

bilirubinuria ( J:216646 )

Allelic Composition	Abcc2^tm1Ahs/Abcc2^tm1Ahs
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc2^tm1Ahs mutation (0 available); any Abcc2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased liver weight ( J:107822 )

• 20-25% increase in liver weight

abnormal bile secretion ( J:107822 )

• bile flow reduced to 37% normal

abnormal liver physiology ( J:107822 )

• 2 fold increase in liver levels of the multidrug transporter Abcc3

• output of total bilirubin and glutathione reduced

renal/urinary system

bilirubinuria ( J:107822 )

• urine levels of total bilirubin are increased seven fold

abnormal kidney physiology ( J:107822 )

• 2 fold increase in kidney levels of the multidrug transporter Abcc4

homeostasis/metabolism

abnormal blood homeostasis ( J:107822 )

increased circulating bilirubin level ( J:107822 )

• plasma levels of total bilirubin are moderately elevated

bilirubinuria ( J:107822 )

• urine levels of total bilirubin are increased seven fold

abnormal xenobiotic pharmacokinetics ( J:107822 )

• reduced ability to clear heterocyclic amines (dietary carcinogens) from plasma

• higher levels of the anticancer drug MTX accumulate in the plasma, particularly at higher doses

hematopoietic system

decreased hemoglobin content ( J:107822 )

• hemoglobin concentration in the blood somewhat reduced

growth/size/body

increased liver weight ( J:107822 )

• 20-25% increase in liver weight

Allelic Composition	Abcb1a^tm1Bor/Abcb1a^tm1Bor Abcb1b^tm1Bor/Abcb1b^tm1Bor Abcc2^tm1Ahs/Abcc2^tm1Ahs
Genetic Background	FVB.129P2-Abcb1b^tm1Bor Abcb1a^tm1Bor Abcc2^tm1Ahs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1a^tm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1b^tm1Bor mutation (2 available); any Abcb1b mutation (84 available)
Abcc2^tm1Ahs mutation (0 available); any Abcc2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:107822 )

• bilary excretion of doxorubicin is reduced to about 2% normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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