Phenotypes associated with this allele

• Allele Symbol: Dkk3^tm1Cni
• Allele Name: targeted mutation 1, Christof Niehrs
• Allele ID: MGI:3621929
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dkk3^tm1Cni/Dkk3^tm1Cni	involves: 129X1/SvJ * C57BL/6	MGI:3622114
cx2	Dkk3^tm1Cni/Dkk3^tm1Cni Kcnk3^tm1Sgb/Kcnk3^tm1Sgb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5444118

Genotype
MGI:3622114

hm1

• Allelic Composition: Dkk3^tm1Cni/Dkk3^tm1Cni
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperactivity ( J:106922 )

♀ • female mice are hyperactive; there are trends to increased velocity, increased rearing, exploration and reduced grooming in female mutants

immune system

decreased NK cell number ( J:106922 )

♀ • there is a slight but significant decrease in the frequency of natural killer cells in female mutants

increased IgM level ( J:106922 )

• the IgM level is 2 fold higher than controls

hematopoietic system

increased hematocrit ( J:106922 )

• mutants have an increased hematocrit

increased hemoglobin content ( J:106922 )

• mutants have increased total hemoglobin content in blood

increased mean corpuscular hemoglobin ( J:106922 )

• mutants have a higher mean hemoglocin content compared to wild-type

increased mean corpuscular volume ( J:106922 )

• mutants have a higher mean corpuscular volume compared to wild-type

decreased NK cell number ( J:106922 )

♀ • there is a slight but significant decrease in the frequency of natural killer cells in female mutants

increased IgM level ( J:106922 )

• the IgM level is 2 fold higher than controls

homeostasis/metabolism

increased circulating aldosterone level ( J:188335 )

• on a potassium-rich diet, both males and females exhibit increased plasma aldosterone levels

• however, both males and females have normal plasma aldosterone levels under basal conditions and females exhibit normal adrenal gland and zona glomerulosa morphology

Genotype
MGI:5444118

cx2

• Allelic Composition: Dkk3^tm1Cni/Dkk3^tm1Cni; Kcnk3^tm1Sgb/Kcnk3^tm1Sgb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

homeostasis/metabolism

increased circulating aldosterone level ( J:188335 )

• females and males have severely increased plasma aldosterone levels under basal conditions

• potassium-rich diet does not further increase plasma aldosterone levels