Mouse Genome Informatics
hm1
    Nos1tm2Plh/Nos1tm2Plh
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased (J:106816)
• at 6 weeks of age, ovary weight is decreased compared to wild-type (J:106816)
• at 10 weeks of age, testis weight is decreased compared to wild-type (J:106816)
• only 2 of 6 matings to wild-type males resulted in pregnancy compared to 5 of 6 wild-type mice (J:106816)
(J:106816)

behavior/neurological
• males fail to mount females in the first 15 minutes after setting up matings and no vaginal plugs are seen; however, spermatogenesis is normal

homeostasis/metabolism
• increased in females but not in males

digestive/alimentary system
• in both males and females; however no increase in plasma ketones or leptin levels are detected

growth/size
• body weight is decreased in both males and females

endocrine/exocrine glands
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased (J:106816)
• at 6 weeks of age, ovary weight is decreased compared to wild-type (J:106816)
• at 10 weeks of age, testis weight is decreased compared to wild-type (J:106816)

nervous system
• increased hypothalmic gonadotropin-releasing hormone content in females