About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nos1tm2Plh
targeted mutation 2, Paul L Huang
MGI:3621899
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nos1tm2Plh/Nos1tm2Plh Not Specified MGI:3622116


Genotype
MGI:3622116
hm1
Allelic
Composition
Nos1tm2Plh/Nos1tm2Plh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm2Plh mutation (1 available); any Nos1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased
• at 6 weeks of age, ovary weight is decreased compared to wild-type
• at 10 weeks of age, testis weight is decreased compared to wild-type
• only 2 of 6 matings to wild-type males resulted in pregnancy compared to 5 of 6 wild-type mice

behavior/neurological
• males fail to mount females in the first 15 minutes after setting up matings and no vaginal plugs are seen; however, spermatogenesis is normal

homeostasis/metabolism
• increased in females but not in males

digestive/alimentary system
• in both males and females; however no increase in plasma ketones or leptin levels are detected

growth/size/body
• body weight is decreased in both males and females

endocrine/exocrine glands
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased
• at 6 weeks of age, ovary weight is decreased compared to wild-type
• at 10 weeks of age, testis weight is decreased compared to wild-type

nervous system
• increased hypothalmic gonadotropin-releasing hormone content in females





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory