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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nos1tm2Plh
targeted mutation 2, Paul L Huang
MGI:3621899
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nos1tm2Plh/Nos1tm2Plh Not Specified MGI:3622116


Genotype
MGI:3622116
hm1
Allelic
Composition
Nos1tm2Plh/Nos1tm2Plh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm2Plh mutation (1 available); any Nos1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased (J:106816)
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased (J:106816)
• at 6 weeks of age, ovary weight is decreased compared to wild-type (J:106816)
• at 6 weeks of age, ovary weight is decreased compared to wild-type (J:106816)
• at 10 weeks of age, testis weight is decreased compared to wild-type (J:106816)
• at 10 weeks of age, testis weight is decreased compared to wild-type (J:106816)
• only 2 of 6 matings to wild-type males resulted in pregnancy compared to 5 of 6 wild-type mice (J:106816)
• only 2 of 6 matings to wild-type males resulted in pregnancy compared to 5 of 6 wild-type mice (J:106816)
(J:106816)
(J:106816)

behavior/neurological
• males fail to mount females in the first 15 minutes after setting up matings and no vaginal plugs are seen; however, spermatogenesis is normal (J:106816)
• males fail to mount females in the first 15 minutes after setting up matings and no vaginal plugs are seen; however, spermatogenesis is normal (J:106816)

homeostasis/metabolism
• decreased in males (J:106816)
• decreased in males (J:106816)
• increased in females but not in males (J:106816)
• increased in females but not in males (J:106816)

digestive/alimentary system
• in both males and females; however no increase in plasma ketones or leptin levels are detected (J:106816)
• in both males and females; however no increase in plasma ketones or leptin levels are detected (J:106816)

growth/size/body
• body weight is decreased in both males and females (J:106816)
• body weight is decreased in both males and females (J:106816)

endocrine/exocrine glands
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased (J:106816)
• marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased (J:106816)
• at 6 weeks of age, ovary weight is decreased compared to wild-type (J:106816)
• at 6 weeks of age, ovary weight is decreased compared to wild-type (J:106816)
• at 10 weeks of age, testis weight is decreased compared to wild-type (J:106816)
• at 10 weeks of age, testis weight is decreased compared to wild-type (J:106816)

nervous system
• increased hypothalmic gonadotropin-releasing hormone content in females (J:106816)
• increased hypothalmic gonadotropin-releasing hormone content in females (J:106816)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory