Mouse Genome Informatics
hm1
    Aaastm1Ahue/Aaastm1Ahue
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• females, but not males, are infertile; however follicular development and ovulation appear to be normal (J:106908)

behavior/neurological
• slight decrease in exploratory behavior for males in a light-dark transition assay and females during a wire hang task; however grip strength is normal and the total number of light dark transitions is similar to wild-type
• at 10 weeks of age, males fall of a rotating rod sooner than wild-type; however no significant difference is seen at any other age or in females at the same age
• slightly less active in an open field; however, in a viewing jar and arena behavior appears normal and no abnormal reflexes are detected

growth/size
• decreased body weight at 8 and 10 weeks of age in female and male homozygotes, respectively

endocrine/exocrine glands
N
• histology of the adrenal gland, pituitary gland, ovary and testes appears normal (J:106908)

cellular
N
• nuclear pore complex structure and function in the liver, kidney and MEFs appears normal (J:106908)

homeostasis/metabolism
N
• plasma levels of adrenocorticotropic hormone and corticosterone are similar to wild-type (J:106908)

nervous system
N
• peripheral nerve histology appears normal (J:106908)

digestive/alimentary system
N
• histology of the esophagus appears normal (J:106908)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Achalasia-Addisonianism-Alacrima Syndrome; AAAS 231550 J:106908