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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
nmf418
neuroscience mutagenesis facility, 418
MGI:3621487
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
nmf418/nmf418 B6;CByJ-nmf418/J MGI:3621641


Genotype
MGI:3621641
hm1
Allelic
Composition
nmf418/nmf418
Genetic
Background
B6;CByJ-nmf418/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
nmf418 mutation (1 available); any nmf418 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• despite weakness, spasms and occasional flaccidity of the hind limbs, no abnormalities were observed upon microscopic examination of fluorescent bungarotoxin, SV2 or SMI 31 labeled whole hind limb muscle mounts from a 59 day old mutant mouse
• from 4.6 +/- 2.2 weeks of age, homozygous mutant mice exhibit intermittent spasms of the hind limbs, which become progressively more severe
• hind limbs of older mutant mice are usually clasped close to the body, but sometimes become flaccid while the mouse is moving or sitting and may cross over one another or become intertwined

limbs/digits/tail
N
• from 4.6 +/- 2.2 weeks of age, homozygous mice exhibit curling of the toes of the front and/or hind paws

behavior/neurological
N
• despite weakness, spasms and occasional flaccidity of the hind limbs, mutant mice exhibit a brisk hind limb flexor response
• when lifted by the tail, a mutant mouse keeps its hind limbs clasped close to its body

nervous system
• standard pathological analysis of two mice aged 10 and 31 days revealed thin cerebellar folia in the older mouse





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory