All Phenotypes Hprt1<tm1(Pck1-cre)Vhh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^{tm1(Pck1-cre)Vhh}
targeted mutation 1, Volker H Haase
MGI:3621174

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Miox^tm1Ysk/Miox^tm1Ysk Hprt1^{tm1(Pck1-cre)Vhh}/Hprt1⁺	B6.129-Miox^tm1Ysk Hprt1^{tm1(Pck1-cre)Vhh}	MGI:6267414
cn2	Dicer1^tm1Bdh/Dicer1^tm1Bdh Hprt1^{tm1(Pck1-cre)Vhh}/Y	involves: 129 * 129P2/OlaHsd	MGI:5437747
cn3	Agtr1a^tm1.1Cof/Agtr1a^tm1.1Cof Hprt1^{tm1(Pck1-cre)Vhh}/Hprt1⁺	involves: 129 * 129P2/OlaHsd	MGI:5007681
cn4	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae	involves: 129 * BALB/c * C57BL/6	MGI:3621461
cn5	Arnt^tm1Bra/Arnt^tm1Bra Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae	involves: 129 * BALB/c * C57BL/6	MGI:3621462
cn6	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hprt1^{tm1(Pck1-cre)Vhh}/Y	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:4418525
cn7	Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6	MGI:3621460
cn8	Hprt1^{tm1(Pck1-cre)Vhh}/Hprt1⁺ Tg(CAG-lacZ,-Miox)#Ysk/0	involves: 129P2/OlaHsd * C57BL/6J	MGI:6267415
cn9	Pdss2^tm1Dalg/Pdss2^tm1Dalg Hprt1^{tm1(Pck1-cre)Vhh}/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3805707

Allelic Composition	Miox^tm1Ysk/Miox^tm1Ysk Hprt1^{tm1(Pck1-cre)Vhh}/Hprt1⁺
Genetic Background	B6.129-Miox^tm1Ysk Hprt1^{tm1(Pck1-cre)Vhh}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)
Miox^tm1Ysk mutation (0 available); any Miox mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:266834 )

• mice exhibit ameliorated cisplatin-induced acute kidney injury with reduced weight loss and minimal elevation of serum creatinine or urea levels, and mild cytolysis of tubular cells and loss of brush border but no renal tubular cell apoptosis or induction of reactive oxygen species generation compared with wild-type mice

growth/size/body

decreased susceptibility to weight loss ( J:266834 )

• induced by cisplatin

Allelic Composition	Dicer1^tm1Bdh/Dicer1^tm1Bdh Hprt1^{tm1(Pck1-cre)Vhh}/Y
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1Bdh mutation (4 available); any Dicer1 mutation (94 available)
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:185838 )

N	• mice exhibit normal kidney size, renal histology, and renal function throughout a 6-month observation period • at 8-10 weeks of age, BUN levels and serum creatinine levels are normal relative to those in wild-type controls

decreased susceptibility to kidney reperfusion injury ( J:185838 )

• following bilateral kidney ischemia/reperfusion injury, mice exhibit decreased creatinine plasma levels, significantly less cortical and outer medulla tubular damage, lower tubular apoptosis, and improved survival relative to wild-type controls

homeostasis/metabolism

decreased susceptibility to kidney reperfusion injury ( J:185838 )

Allelic Composition	Agtr1a^tm1.1Cof/Agtr1a^tm1.1Cof Hprt1^{tm1(Pck1-cre)Vhh}/Hprt1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1a^tm1.1Cof mutation (0 available); any Agtr1a mutation (40 available)
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:172240 )

• decreased during both the night and day

• responses to high salt diet and vasoconstrictors are similar to wild-type controls

renal/urinary system

abnormal renal water reabsorption ( J:172240 )

• absolute rates of proximal fluid reabsorption are reduced

• fractional reabsorption rates, corrected for single nephron glomerular filtration rate, are reduced

decreased renal glomerular filtration rate ( J:172240 )

• decrease in single nephron glomerular filtration rate in the proximal tubules

homeostasis/metabolism

abnormal renal water reabsorption ( J:172240 )

• absolute rates of proximal fluid reabsorption are reduced

• fractional reabsorption rates, corrected for single nephron glomerular filtration rate, are reduced

Allelic Composition	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1a^tm3Rsjo mutation (3 available); any Hif1a mutation (48 available)
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)
Vhl^tm1Jae mutation (2 available); any Vhl mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney inflammation ( J:106705 )

• pockets of inflammation

abnormal kidney morphology ( J:106705 )

• dilated lymphatic vessels

abnormal kidney vasculature morphology ( J:106705 )

• vascular ectasia

kidney cyst ( J:106705 )

• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 3 of 10 mice

• multiple microscopic cysts are also seen with 3 of 10 having cysts of tubular origin and 7 of 10 having cysts of glomerular origin

• cysts of both tubular and glomerular origin may occur in the same mouse

liver/biliary system

hepatic steatosis ( J:97652 )

increased hepatic hemangioma incidence ( J:97652 )

• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months

cardiovascular system

increased vascular endothelial cell number ( J:97652 )

• proliferation of endothelial cells in hepatic blood vessels

abnormal kidney vasculature morphology ( J:106705 )

• vascular ectasia

abnormal vasodilation ( J:97652 )

• hepatic vascular angiectasia

neoplasm

increased hepatic hemangioma incidence ( J:97652 )

• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months

hematopoietic system

polycythemia ( J:97652 )

• average red blood cell count is 10.77 x 10⁶ compared to 9.3 x 10⁶ in controls

• develop erythrocytosis as indicated by reddening of paws and muzzle

increased hemoglobin content ( J:97652 )

• hemoglobin content is 19.38 g/dl compared to 13.24 g/dl in controls

immune system

kidney inflammation ( J:106705 )

• pockets of inflammation

muscle

abnormal vasodilation ( J:97652 )

• hepatic vascular angiectasia

growth/size/body

kidney cyst ( J:106705 )

• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 3 of 10 mice

• multiple microscopic cysts are also seen with 3 of 10 having cysts of tubular origin and 7 of 10 having cysts of glomerular origin

• cysts of both tubular and glomerular origin may occur in the same mouse

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
von Hippel-Lindau disease		DOID:14175	OMIM:193300	J:97652 , J:106705

Allelic Composition	Arnt^tm1Bra/Arnt^tm1Bra Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1Bra mutation (0 available); any Arnt mutation (62 available)
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)
Vhl^tm1Jae mutation (2 available); any Vhl mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:106705 )

N	• no macroscopic or microscopic renal cysts are detected

liver/biliary system

hepatic steatosis ( J:97652 )

• moderate steatosis without angiectasia or endothelial cell proliferation is seen only in mutants over 9 months of age

neoplasm

neoplasm ( J:97652 )

N	• no hepatic hemangiomas are seen

hematopoietic system

hematopoietic system phenotype ( J:97652 )

N	• red cell count and hemoglobin levels are similar to controls

Allelic Composition	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Hprt1^{tm1(Pck1-cre)Vhh}/Y
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Hif1a^tm3Rsjo mutation (3 available); any Hif1a mutation (48 available)
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney inflammation ( J:130751 )

• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ mice

renal fibrosis ( J:130751 )

• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ mice

cellular

abnormal cell differentiation ( J:130751 )

• hypoxic primary tubular epithelial cells fails to undergo an epithelial to mesenchyme transition unlike similarly treated cells from Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ mice

homeostasis/metabolism

decreased susceptibility to injury ( J:130751 )

• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ mice

immune system

kidney inflammation ( J:130751 )

• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ mice

Allelic Composition	Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)
Vhl^tm1Jae mutation (2 available); any Vhl mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney inflammation ( J:106705 )

• pockets of inflammation

abnormal kidney morphology ( J:106705 )

• dilated lymphatic vessels

abnormal kidney vasculature morphology ( J:106705 )

• vascular ectasia

kidney cyst ( J:106705 )

• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 4 of 22 mice

• multiple microscopic cysts are also seen with 5 of 20 having cysts of tubular origin and 7 of 20 having cysts of glomerular origin

• cysts of both tubular and glomerular origin may occur in the same mouse

liver/biliary system

hepatic steatosis ( J:97652 )

increased hepatic hemangioma incidence ( J:97652 )

• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months

cardiovascular system

increased vascular endothelial cell number ( J:97652 )

• proliferation of endothelial cells in hepatic blood vessels

abnormal kidney vasculature morphology ( J:106705 )

• vascular ectasia

abnormal vasodilation ( J:97652 )

• hepatic vascular angiectasia

neoplasm

increased hepatic hemangioma incidence ( J:97652 )

• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months

hematopoietic system

polycythemia ( J:97652 )

• average red blood cell count is 11.7 x 10⁶ compared to 9.3 x 10⁶ in controls

• develop erythrocytosis as indicated by reddening of paws and muzzle

increased hemoglobin content ( J:97652 )

• hemoglobin content is 20.05 g/dl compared to 13.24 g/dl in controls

immune system

kidney inflammation ( J:106705 )

• pockets of inflammation

muscle

abnormal vasodilation ( J:97652 )

• hepatic vascular angiectasia

growth/size/body

kidney cyst ( J:106705 )

• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 4 of 22 mice

• multiple microscopic cysts are also seen with 5 of 20 having cysts of tubular origin and 7 of 20 having cysts of glomerular origin

• cysts of both tubular and glomerular origin may occur in the same mouse

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
von Hippel-Lindau disease		DOID:14175	OMIM:193300	J:97652 , J:106705

Allelic Composition	Hprt1^{tm1(Pck1-cre)Vhh}/Hprt1⁺ Tg(CAG-lacZ,-Miox)#Ysk/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)
Tg(CAG-lacZ,-Miox)#Ysk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased renal tubule apoptosis ( J:266834 )

• induced by cisplatin

homeostasis/metabolism

increased circulating creatinine level ( J:266834 )

• induced by cisplatin

increased blood urea nitrogen level ( J:266834 )

• induced by cisplatin

increased susceptibility to injury ( J:266834 )

• mice exhibit worsened cisplatin-induced acute kidney injury with increased weight loss, serum creatinine and urea levels, and fulminant apoptosis of renal tubular cells, and accentuated cytolysis of tubular cells with loss of brush border and reactive oxygen species generation compared with wild-type mice

cellular

increased renal tubule apoptosis ( J:266834 )

• induced by cisplatin

oxidative stress ( J:266834 )

• induced by cisplatin

Allelic Composition	Pdss2^tm1Dalg/Pdss2^tm1Dalg Hprt1^{tm1(Pck1-cre)Vhh}/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(Pck1-cre)Vhh} mutation (0 available); any Hprt1 mutation (1273 available)
Pdss2^tm1Dalg mutation (0 available); any Pdss2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:136670 )

N	• kidney ultrastructure normal • no evidence of nephritis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:136670 )

N	• normal urine albumin levels

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