Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6tm1c(EUCOMM)Wtsi mutation
(1 available);
any
Abcc6 mutation
(74 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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integument
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N |
• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.1Fsl mutation
(0 available);
any
Egln1 mutation
(21 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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cardiovascular system
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• increased cardiac mass as compared to controls
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mortality/aging
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• less than half of mice survive to 6 months of age
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growth/size/body
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• increased cardiac mass as compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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growth/size/body
mortality/aging
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N |
• contrary to previous reports, viable mice are produced
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cardiovascular system
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• abnormal positioning of the aorta and pulmonary trunk
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• abnormal positioning of the aorta and pulmonary trunk
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• fragile and hemorrhaging in embryos and neonates
• thin and disorganized
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• large and hyperplastic (myxomatous)
• neonates exhibit bulges near the valve annulus
• cartilage nodules and calcification in the annulus of adults
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• thick at P10 with lower nuclear density indicating changes in the extracellular matrix rather than increase in cell density
• increased outflow tract valve leaflet width in adults
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• with severe regurgitation at the pulmonic valve
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muscle
liver/biliary system
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N |
• mice exhibit normal bile duct formation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxltm2Kmn mutation
(0 available);
any
Podxl mutation
(16 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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cardiovascular system
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• isolated primary mouse pulmonary endothelial cells (mECs) display a severely impaired ability to spread on laminin and, to a lesser extent, collagen I coated transwells
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• isolated primary mouse pulmonary endothelial cells (mECs) show a significant increase in static adhesion to fibronectin but not to laminin, collagen (type I or type IV) or gelatin relative to control cells
• however, mECs spread normally when plated on fibronectin-coated transwells
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• 2-fold increase in basal lung vascular permeability, as shown by Evans blue dye vascular leakage assays on naive mice
• additional increase in inflammation-induced lung vascular permeability following intra-tracheal LPS treatment
• however, no detectable changes in the ratio of wet/dry lung weight, in vascular density, or in the frequency and phenotype of endothelial cells relative to controls
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respiratory system
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• isolated primary mouse pulmonary endothelial cells (mECs) display a severely impaired ability to spread on laminin and, to a lesser extent, collagen I coated transwells
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• isolated primary mouse pulmonary endothelial cells (mECs) show a significant increase in static adhesion to fibronectin but not to laminin, collagen (type I or type IV) or gelatin relative to control cells
• however, mECs spread normally when plated on fibronectin-coated transwells
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• mislocalization of structural matrix proteins in the lung
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• increase in airspace size upon lung inflation at a fixed pressure with an open thoracic cavity, as shown by increased mean linear intercept (MLI) at 10 weeks but not at 1-3 weeks of age
• however, normal sized airspace and alveolar architecture upon lung inflation with a constant volume under closed chest conditions at 10 weeks of age
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• >30% increase in elastin-free fibrillar collagen fibers in alveolar lung tissue, primarily in larger alveolar spaces
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• density of elastin fiber staining is marginally decreased within lung parenchyma tissue as shown by Gomoris aldehyde fuchsin staining, despite an observed increase in elastin transcript levels
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• increase in mean lung volume upon inflation at constant pressure with an open thoracic cavity at 4 and 10 weeks of age
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• increased total lung and airway resistance under closed chest conditions
• however, no significant alterations in total lung capacity or compliance
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cellular
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• isolated primary mouse pulmonary endothelial cells (mECs) display a severely impaired ability to spread on laminin and, to a lesser extent, collagen I coated transwells
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• isolated primary mouse pulmonary endothelial cells (mECs) show a significant increase in static adhesion to fibronectin but not to laminin, collagen (type I or type IV) or gelatin relative to control cells
• however, mECs spread normally when plated on fibronectin-coated transwells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Notch1tm1Agt mutation
(0 available);
any
Notch1 mutation
(115 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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cardiovascular system
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• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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cardiovascular system
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• temporarily delayed at E10.5
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• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Senp1tm1Wami mutation
(0 available);
any
Senp1 mutation
(65 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3tm1.1Chav mutation
(0 available);
any
Jam3 mutation
(24 available)
Jam3tm1.2Chav mutation
(0 available);
any
Jam3 mutation
(24 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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neoplasm
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• significantly reduced B16 melanoma lung metastasis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm1.1Rmnt mutation
(1 available);
any
F8 mutation
(24 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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mortality/aging
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• die before P68 with vascular complications
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hematopoietic system
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• 100% of mutants develop myeloproliferative disorder at about P30
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cardiovascular system
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• mutants exhibit vascular complication
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation
(1 available);
any
Rapgef2 mutation
(82 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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hematopoietic system
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N |
• mice exhibit normal adult hematopoiesis
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immune system
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N |
• mice exhibit normal B cell and T cell development
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hematopoietic system
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• 70% of mutants exhibit enlarged thymus
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• progressive development of myeloproliferative disorder and leukemogenesis in the chronic phase followed by blast crisis
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• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs
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• one month after birth, mutants develop a myeloid shift with increased neutrophil counts
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immune system
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• 70% of mutants exhibit enlarged thymus
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• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs
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• one month after birth, mutants develop a myeloid shift with increased neutrophil counts
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• 70% of mutants exhibit enlarged lymph nodes
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liver/biliary system
neoplasm
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• 74% of mutants develop T-lymphoblastic leukemia
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• 26% of mutants develop acute myeloid leukemia
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endocrine/exocrine glands
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• 70% of mutants exhibit enlarged thymus
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growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcur1tm1c(KOMP)Wtsi mutation
(0 available);
any
Mcur1 mutation
(20 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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respiratory system
homeostasis/metabolism
cellular
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• endothelial cell and fibroblast mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcbld2tm1.1Mhms mutation
(0 available);
any
Dcbld2 mutation
(47 available)
Dcbld2tm1Mhms mutation
(0 available);
any
Dcbld2 mutation
(47 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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Decreased retinal angiogenesis in Dcbld2tm1Mhms/Dcbld2tm1.1Mhms Tg(Cdh5-cre)7Mlia/0 mice
cardiovascular system
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• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice
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• reduced pericyte staining
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• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice
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vision/eye
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• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcutm1.1Jmol mutation
(2 available);
any
Mcu mutation
(27 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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cellular
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• cardiomyocytes, endothelial cells and fibroblast mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells
• however, mitochondrial membrane potential is normal
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respiratory system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Glh mutation
(0 available);
any
Acvr1 mutation
(44 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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skeleton
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N |
• pinch-mediated injury of the gastrocnemius or tibialis anterior hindlimb muscles of adults does not cause heterotopic ossification
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2axtm1Nus mutation
(1 available);
any
H2ax mutation
(7 available)
H2axtm2.1Fwa mutation
(0 available);
any
H2ax mutation
(7 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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cardiovascular system
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• hypoxia induced retinal neovascularization is decreased compared to controls
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• vascularization of implanted tumors is reduced compared to controls
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neoplasm
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• vascularization of implanted tumors is reduced compared to controls
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• growth of implanted Lewis lung carcinomas is reduced compared to controls
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vision/eye
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• hypoxia induced retinal neovascularization is decreased compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1Mlia mutation
(0 available);
any
Pgr mutation
(73 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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reproductive system
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• 43% reduction in the number of implantation sites compared to controls
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• change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced
• increase in albumin extravasation during pregnancy is significantly reduced
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cardiovascular system
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• changes in permeability of uterine vasculature following hormone treatment (E2 + P4) and during pregnancy are significantly reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1tm1.1Wami mutation
(0 available);
any
Epn1 mutation
(32 available)
Epn2tm1Ocr mutation
(0 available);
any
Epn2 mutation
(73 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 and Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre)7Mlia/0 mice
neoplasm
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• mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer tumors that grow at a slower rate compared with control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora2btm1Msit mutation
(0 available);
any
Adora2b mutation
(19 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicraem3Hzhg mutation
(0 available);
any
Bicra mutation
(55 available)
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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mortality/aging
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• mice exhibit normal embryonic survival
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cardiovascular system
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• mice exhibit normal cardiac phenotype
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cdh5-cre)7Mlia mutation
(1 available)
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normal phenotype
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• mice are viable and fertile; no phenotypic abnormalities are detected
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Analysis Tools
