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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cdh5-cre)7Mlia
transgene insertion 7, M Luisa Iruela-Arispe
MGI:3620560
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Cdh5-cre)7Mlia/0
B6.Cg-Egln1tm2.1Fsl Tg(Cdh5-cre)7Mlia MGI:5525142
cn2
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia MGI:5447166
cn3
Notch1tm1Agt/Notch1tm1Agt
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129 * 129S4/SvJaeSor * FVB/N MGI:5447168
cn4
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129 * 129S4/SvJaeSor * FVB/N MGI:5447167
cn5
Jam3tm1.1Chav/Jam3tm1.2Chav
Tg(Cdh5-cre)7Mlia/?
involves: 129 * C57BL/6 * FVB/N MGI:5140203
cn6
F8tm1.1Rmnt/F8tm1.1Rmnt
Tg(Cdh5-cre)7Mlia/0
involves: 129 * C57BL/6 * FVB/N * SJL MGI:5582834
cn7
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N MGI:4839561
cn8
Ctnnb1tm2Kem/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N MGI:4839562
cn9
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * FVB/N MGI:4839187
cn10
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N MGI:4839560
cn11
Dcbld2tm1Mhms/Dcbld2tm1.1Mhms
Tg(Cdh5-cre)7Mlia/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:5569330
cn12
H2afxtm1Nus/H2afxtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0
involves: 129S6/SvEvTac * FVB/N MGI:3849332
cn13
Pgrtm1.1Mlia/Pgrtm1.1Mlia
Tg(Cdh5-cre)7Mlia/0
involves: 129X1/SvJ * FVB/N MGI:5566877
cn14
Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre)7Mlia/0
involves: C57BL/6J * FVB/N MGI:5477819
tg15
Tg(Cdh5-cre)7Mlia/0 involves: FVB/N MGI:3665410


Genotype
MGI:5525142
cn1
Allelic
Composition
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
B6.Cg-Egln1tm2.1Fsl Tg(Cdh5-cre)7Mlia
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.1Fsl mutation (0 available); any Egln1 mutation (4 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased cardiac mass as compared to controls (J:202737)
• increased cardiac mass as compared to controls (J:202737)

mortality/aging
• less than half of mice survive to 6 months of age (J:202737)
• less than half of mice survive to 6 months of age (J:202737)




Genotype
MGI:5447166
cn2
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation (0 available); any Jag1 mutation (8 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• contrary to previous reports, viable mice are produced (J:166890)
• contrary to previous reports, viable mice are produced (J:166890)

cardiovascular system
• abnormal positioning of the aorta and pulmonary trunk (J:189213)
• abnormal positioning of the aorta and pulmonary trunk (J:189213)
• abnormal positioning of the aorta and pulmonary trunk (J:189213)
• abnormal positioning of the aorta and pulmonary trunk (J:189213)
• fragile and hemorrhaging in embryos and neonates (J:189213)
• thin and disorganized (J:189213)
• fragile and hemorrhaging in embryos and neonates (J:189213)
• thin and disorganized (J:189213)
• hypertrophy (J:189213)
• hypertrophy (J:189213)
• incomplete at E14.5 (J:189213)
• incomplete at E14.5 (J:189213)
• large and hyperplastic (myxomatous) (J:189213)
• neonates exhibit bulges near the valve annulus (J:189213)
• cartilage nodules and calcification in the annulus of adults (J:189213)
• large and hyperplastic (myxomatous) (J:189213)
• neonates exhibit bulges near the valve annulus (J:189213)
• cartilage nodules and calcification in the annulus of adults (J:189213)
• thick at P10 with lower nuclear density indicating changes in the extracellular matrix rather than increase in cell density (J:189213)
• increased outflow tract valve leaflet width in adults (J:189213)
• thick at P10 with lower nuclear density indicating changes in the extracellular matrix rather than increase in cell density (J:189213)
• increased outflow tract valve leaflet width in adults (J:189213)
• increased area (J:189213)
• increased area (J:189213)
• in right ventricle (J:189213)
• in right ventricle (J:189213)
• near the apex (J:189213)
• near the apex (J:189213)
• severe (J:189213)
• severe (J:189213)
• with severe regurgitation at the pulmonic valve (J:189213)
• with severe regurgitation at the pulmonic valve (J:189213)

liver/biliary system
N
• mice exhibit normal bile duct formation (J:166890)
• mice exhibit normal bile duct formation (J:166890)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alagille Syndrome 1; ALGS1 118450 J:189213




Genotype
MGI:5447168
cn3
Allelic
Composition
Notch1tm1Agt/Notch1tm1Agt
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (302 available)
Notch1tm1Agt mutation (0 available); any Notch1 mutation (34 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• arrested (J:189213)
• arrested (J:189213)
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice (J:189213)
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice (J:189213)




Genotype
MGI:5447167
cn4
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (302 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (8 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• temporarily delayed at E10.5 (J:189213)
• temporarily delayed at E10.5 (J:189213)
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice (J:189213)
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice (J:189213)




Genotype
MGI:5140203
cn5
Allelic
Composition
Jam3tm1.1Chav/Jam3tm1.2Chav
Tg(Cdh5-cre)7Mlia/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3tm1.1Chav mutation (0 available); any Jam3 mutation (6 available)
Jam3tm1.2Chav mutation (0 available); any Jam3 mutation (6 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• significantly reduced B16 melanoma lung metastasis (J:173391)
• significantly reduced B16 melanoma lung metastasis (J:173391)




Genotype
MGI:5582834
cn6
Allelic
Composition
F8tm1.1Rmnt/F8tm1.1Rmnt
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm1.1Rmnt mutation (1 available); any F8 mutation (3 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:4839561
cn7
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (17 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (37 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryonic lethal (J:135172)
• embryonic lethal (J:135172)




Genotype
MGI:4839562
cn8
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (17 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (37 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die before P68 with vascular complications (J:135172)
• die before P68 with vascular complications (J:135172)

hematopoietic system
• 100% of mutants develop myeloproliferative disorder at about P30 (J:135172)
• 100% of mutants develop myeloproliferative disorder at about P30 (J:135172)

cardiovascular system
• mutants exhibit vascular complication (J:135172)
• mutants exhibit vascular complication (J:135172)




Genotype
MGI:4839187
cn9
Allelic
Composition
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (0 available); any Rapgef2 mutation (12 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal adult hematopoiesis (J:165879)
• mice exhibit normal adult hematopoiesis (J:165879)

immune system
N
• mice exhibit normal B cell and T cell development (J:165879)
• mice exhibit normal B cell and T cell development (J:165879)




Genotype
MGI:4839560
cn10
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (37 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 70% of mutants exhibit enlarged thymus (J:135172)
• 70% of mutants exhibit enlarged thymus (J:135172)
• progressive development of myeloproliferative disorder and leukemogenesis in the chronic phase followed by blast crisis (J:135172)
• progressive development of myeloproliferative disorder and leukemogenesis in the chronic phase followed by blast crisis (J:135172)
• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs (J:135172)
• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs (J:135172)
• one month after birth, mutants develop a myeloid shift with increased neutrophil counts (J:135172)
• one month after birth, mutants develop a myeloid shift with increased neutrophil counts (J:135172)
• splenomegaly (J:135172)
• splenomegaly (J:135172)

immune system
• 70% of mutants exhibit enlarged thymus (J:135172)
• 70% of mutants exhibit enlarged thymus (J:135172)
• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs (J:135172)
• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs (J:135172)
• one month after birth, mutants develop a myeloid shift with increased neutrophil counts (J:135172)
• one month after birth, mutants develop a myeloid shift with increased neutrophil counts (J:135172)
• splenomegaly (J:135172)
• splenomegaly (J:135172)
• 70% of mutants exhibit enlarged lymph nodes (J:135172)
• 70% of mutants exhibit enlarged lymph nodes (J:135172)

liver/biliary system
• hepatomegaly (J:135172)
• hepatomegaly (J:135172)

tumorigenesis
• 74% of mutants develop T-lymphoblastic leukemia (J:135172)
• 74% of mutants develop T-lymphoblastic leukemia (J:135172)
• 26% of mutants develop acute myeloid leukemia (J:135172)
• 26% of mutants develop acute myeloid leukemia (J:135172)

endocrine/exocrine glands
• 70% of mutants exhibit enlarged thymus (J:135172)
• 70% of mutants exhibit enlarged thymus (J:135172)




Genotype
MGI:5569330
cn11
Allelic
Composition
Dcbld2tm1Mhms/Dcbld2tm1.1Mhms
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcbld2tm1.1Mhms mutation (0 available); any Dcbld2 mutation (3 available)
Dcbld2tm1Mhms mutation (0 available); any Dcbld2 mutation (3 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decreased retinal angiogenesis in Dcbld2tm1Mhms/Dcbld2tm1.1Mhms Tg(Cdh5-cre)7Mlia/0 mice

cardiovascular system
• reduced pericyte staining (J:207629)
• reduced pericyte staining (J:207629)
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice (J:207629)
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice (J:207629)
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice (J:207629)
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice (J:207629)

vision/eye
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice (J:207629)
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice (J:207629)




Genotype
MGI:3849332
cn12
Allelic
Composition
H2afxtm1Nus/H2afxtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2afxtm1Nus mutation (0 available); any H2afx mutation (1 available)
H2afxtm2.1Fwa mutation (0 available); any H2afx mutation (1 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hypoxia induced retinal neovascularization is decreased compared to controls (J:149487)
• hypoxia induced retinal neovascularization is decreased compared to controls (J:149487)
• vascularization of implanted tumors is reduced compared to controls (J:149487)
• vascularization of implanted tumors is reduced compared to controls (J:149487)

tumorigenesis
• vascularization of implanted tumors is reduced compared to controls (J:149487)
• vascularization of implanted tumors is reduced compared to controls (J:149487)
• growth of implanted Lewis lung carcinomas is reduced compared to controls (J:149487)
• growth of implanted Lewis lung carcinomas is reduced compared to controls (J:149487)

vision/eye
• hypoxia induced retinal neovascularization is decreased compared to controls (J:149487)
• hypoxia induced retinal neovascularization is decreased compared to controls (J:149487)




Genotype
MGI:5566877
cn13
Allelic
Composition
Pgrtm1.1Mlia/Pgrtm1.1Mlia
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1Mlia mutation (0 available); any Pgr mutation (8 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 43% reduction in the number of implantation sites compared to controls (J:205553)
• 43% reduction in the number of implantation sites compared to controls (J:205553)
• change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced (J:205553)
• increase in albumin extravasation during pregnancy is significantly reduced (J:205553)
• change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced (J:205553)
• increase in albumin extravasation during pregnancy is significantly reduced (J:205553)

cardiovascular system
• changes in permeability of uterine vasculature following hormone treatment (E2 + P4) and during pregnancy are significantly reduced (J:205553)
• changes in permeability of uterine vasculature following hormone treatment (E2 + P4) and during pregnancy are significantly reduced (J:205553)




Genotype
MGI:5477819
cn14
Allelic
Composition
Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1tm1.1Wami mutation (0 available); any Epn1 mutation (1 available)
Epn2tm1Ocr mutation (0 available); any Epn2 mutation (50 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 and Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre)7Mlia/0 mice

tumorigenesis
• mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer tumors that grow at a slower rate compared with control mice (J:193966)
• mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer tumors that grow at a slower rate compared with control mice (J:193966)




Genotype
MGI:3665410
tg15
Allelic
Composition
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile; no phenotypic abnormalities are detected (J:106155)
• mice are viable and fertile; no phenotypic abnormalities are detected (J:106155)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory