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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cdh5-cre)7Mlia
transgene insertion 7, M Luisa Iruela-Arispe
MGI:3620560
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Cdh5-cre)7Mlia/0
B6.Cg-Egln1tm2.1Fsl Tg(Cdh5-cre)7Mlia MGI:5525142
cn2
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia MGI:5447166
cn3
Notch1tm1Agt/Notch1tm1Agt
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129 * 129S4/SvJaeSor * FVB/N MGI:5447168
cn4
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129 * 129S4/SvJaeSor * FVB/N MGI:5447167
cn5
Senp1tm1Wami/Senp1tm1Wami
Tg(Cdh5-cre)7Mlia/0
involves: 129 * C57BL/6 * FVB/N MGI:5707798
cn6
Jam3tm1.1Chav/Jam3tm1.2Chav
Tg(Cdh5-cre)7Mlia/?
involves: 129 * C57BL/6 * FVB/N MGI:5140203
cn7
F8tm1.1Rmnt/F8tm1.1Rmnt
Tg(Cdh5-cre)7Mlia/0
involves: 129 * C57BL/6 * FVB/N * SJL MGI:5582834
cn8
Ctnnb1tm2Kem/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N MGI:4839562
cn9
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N MGI:4839561
cn10
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cdh5-cre)7Mlia/0
involves: 129S1/Sv * FVB/N MGI:4839187
cn11
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N MGI:4839560
cn12
Dcbld2tm1Mhms/Dcbld2tm1.1Mhms
Tg(Cdh5-cre)7Mlia/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:5569330
cn13
H2afxtm1Nus/H2afxtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0
involves: 129S6/SvEvTac * FVB/N MGI:3849332
cn14
Pgrtm1.1Mlia/Pgrtm1.1Mlia
Tg(Cdh5-cre)7Mlia/0
involves: 129X1/SvJ * FVB/N MGI:5566877
cn15
Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre)7Mlia/0
involves: C57BL/6J * FVB/N MGI:5477819
tg16
Tg(Cdh5-cre)7Mlia/0 involves: FVB/N MGI:3665410


Genotype
MGI:5525142
cn1
Allelic
Composition
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
B6.Cg-Egln1tm2.1Fsl Tg(Cdh5-cre)7Mlia
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.1Fsl mutation (0 available); any Egln1 mutation (11 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased cardiac mass as compared to controls

mortality/aging
• less than half of mice survive to 6 months of age




Genotype
MGI:5447166
cn2
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
B6.Cg-Jag1tm1Frad Tg(Cdh5-cre)7Mlia
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation (0 available); any Jag1 mutation (31 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• contrary to previous reports, viable mice are produced

cardiovascular system
• abnormal positioning of the aorta and pulmonary trunk
• abnormal positioning of the aorta and pulmonary trunk
• fragile and hemorrhaging in embryos and neonates
• thin and disorganized
• incomplete at E14.5
• large and hyperplastic (myxomatous)
• neonates exhibit bulges near the valve annulus
• cartilage nodules and calcification in the annulus of adults
• thick at P10 with lower nuclear density indicating changes in the extracellular matrix rather than increase in cell density
• increased outflow tract valve leaflet width in adults
• in right ventricle
• near the apex
• with severe regurgitation at the pulmonic valve

liver/biliary system
N
• mice exhibit normal bile duct formation

Mouse Models of Human Disease
OMIM ID Ref(s)
Alagille Syndrome 1; ALGS1 118450 J:189213




Genotype
MGI:5447168
cn3
Allelic
Composition
Notch1tm1Agt/Notch1tm1Agt
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (315 available)
Notch1tm1Agt mutation (0 available); any Notch1 mutation (56 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice




Genotype
MGI:5447167
cn4
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (315 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (31 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice




Genotype
MGI:5707798
cn5
Allelic
Composition
Senp1tm1Wami/Senp1tm1Wami
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Senp1tm1Wami mutation (0 available); any Senp1 mutation (42 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice do not develop hyperglycemia even at 14 weeks of age




Genotype
MGI:5140203
cn6
Allelic
Composition
Jam3tm1.1Chav/Jam3tm1.2Chav
Tg(Cdh5-cre)7Mlia/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jam3tm1.1Chav mutation (0 available); any Jam3 mutation (12 available)
Jam3tm1.2Chav mutation (0 available); any Jam3 mutation (12 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• significantly reduced B16 melanoma lung metastasis




Genotype
MGI:5582834
cn7
Allelic
Composition
F8tm1.1Rmnt/F8tm1.1Rmnt
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm1.1Rmnt mutation (1 available); any F8 mutation (12 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:4839562
cn8
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (40 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die before P68 with vascular complications

hematopoietic system
• 100% of mutants develop myeloproliferative disorder at about P30

cardiovascular system
• mutants exhibit vascular complication




Genotype
MGI:4839561
cn9
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (27 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (40 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4839187
cn10
Allelic
Composition
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef2tm1.1Hous mutation (0 available); any Rapgef2 mutation (28 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal adult hematopoiesis

immune system
N
• mice exhibit normal B cell and T cell development




Genotype
MGI:4839560
cn11
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (40 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 70% of mutants exhibit enlarged thymus
• progressive development of myeloproliferative disorder and leukemogenesis in the chronic phase followed by blast crisis
• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs
• one month after birth, mutants develop a myeloid shift with increased neutrophil counts
• splenomegaly

immune system
• 70% of mutants exhibit enlarged thymus
• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs
• one month after birth, mutants develop a myeloid shift with increased neutrophil counts
• splenomegaly
• 70% of mutants exhibit enlarged lymph nodes

liver/biliary system
• hepatomegaly

neoplasm
• 74% of mutants develop T-lymphoblastic leukemia
• 26% of mutants develop acute myeloid leukemia

endocrine/exocrine glands
• 70% of mutants exhibit enlarged thymus




Genotype
MGI:5569330
cn12
Allelic
Composition
Dcbld2tm1Mhms/Dcbld2tm1.1Mhms
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcbld2tm1.1Mhms mutation (0 available); any Dcbld2 mutation (19 available)
Dcbld2tm1Mhms mutation (0 available); any Dcbld2 mutation (19 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decreased retinal angiogenesis in Dcbld2tm1Mhms/Dcbld2tm1.1Mhms Tg(Cdh5-cre)7Mlia/0 mice

cardiovascular system
• reduced pericyte staining
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

vision/eye
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice




Genotype
MGI:3849332
cn13
Allelic
Composition
H2afxtm1Nus/H2afxtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2afxtm1Nus mutation (0 available); any H2afx mutation (1 available)
H2afxtm2.1Fwa mutation (0 available); any H2afx mutation (1 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hypoxia induced retinal neovascularization is decreased compared to controls
• vascularization of implanted tumors is reduced compared to controls

neoplasm
• vascularization of implanted tumors is reduced compared to controls
• growth of implanted Lewis lung carcinomas is reduced compared to controls

vision/eye
• hypoxia induced retinal neovascularization is decreased compared to controls




Genotype
MGI:5566877
cn14
Allelic
Composition
Pgrtm1.1Mlia/Pgrtm1.1Mlia
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1Mlia mutation (0 available); any Pgr mutation (24 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 43% reduction in the number of implantation sites compared to controls
• change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced
• increase in albumin extravasation during pregnancy is significantly reduced

cardiovascular system
• changes in permeability of uterine vasculature following hormone treatment (E2 + P4) and during pregnancy are significantly reduced




Genotype
MGI:5477819
cn15
Allelic
Composition
Epn1tm1.1Wami/Epn1tm1.1Wami
Epn2tm1Ocr/Epn2tm1Ocr
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epn1tm1.1Wami mutation (0 available); any Epn1 mutation (10 available)
Epn2tm1Ocr mutation (0 available); any Epn2 mutation (56 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 and Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre)7Mlia/0 mice

neoplasm
• mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer tumors that grow at a slower rate compared with control mice




Genotype
MGI:3665410
tg16
Allelic
Composition
Tg(Cdh5-cre)7Mlia/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile; no phenotypic abnormalities are detected





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory