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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(IGL-MYC)3Hm
transgene insertion 3, Herbert Morse
MGI:3619458
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Tg(IGL-MYC)3Hm/0
B6.Cg-Shmt1Gt(AD0236)Wtsi Tg(IGL-MYC)3Hm MGI:5426850
cx2
Ldhaa-m1Neu/Ldhaa-m1Neu
Tg(IGL-MYC)3Hm/0
involves: 101/El * C3H/El * C57BL/6N MGI:5426847
tg3
Tg(IGL-MYC)3Hm/0 C57BL/6N-Tg(IGL-MYC)3Hm MGI:3619459


Genotype
MGI:5426850
cx1
Allelic
Composition
Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Tg(IGL-MYC)3Hm/0
Genetic
Background
B6.Cg-Shmt1Gt(AD0236)Wtsi Tg(IGL-MYC)3Hm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shmt1Gt(AD0236)Wtsi mutation (0 available); any Shmt1 mutation (28 available)
Tg(IGL-MYC)3Hm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice




Genotype
MGI:5426847
cx2
Allelic
Composition
Ldhaa-m1Neu/Ldhaa-m1Neu
Tg(IGL-MYC)3Hm/0
Genetic
Background
involves: 101/El * C3H/El * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldhaa-m1Neu mutation (1 available); any Ldha mutation (16 available)
Tg(IGL-MYC)3Hm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice




Genotype
MGI:3619459
tg3
Allelic
Composition
Tg(IGL-MYC)3Hm/0
Genetic
Background
C57BL/6N-Tg(IGL-MYC)3Hm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IGL-MYC)3Hm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice hemizygous for the transgene die between the ages of 2 and 6 months

immune system
• transgene hemizygotes develop severe lymphadenopathy, but only minimal splenomegaly

neoplasm
• hemizygous transgenics develop clonal B-lineage lymphomas; their spleens and lymph nodes contain "uniform populations of IgM+CD19+CD5-CD23- cells"

Mouse Models of Human Disease
OMIM ID Ref(s)
Burkitt Lymphoma; BL 113970 J:65245





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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory