Mouse Genome Informatics
cx1
    Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Tg(IGL-MYC)3Hm/0

B6.Cg-Shmt1Gt(AD0236)Wtsi Tg(IGL-MYC)3Hm
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice


Mouse Genome Informatics
cx2
    Ldhaa-m1Neu/Ldhaa-m1Neu
Tg(IGL-MYC)3Hm/0

involves: 101/El * C3H/El * C57BL/6N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice


Mouse Genome Informatics
tg3
    Tg(IGL-MYC)3Hm/0
C57BL/6N-Tg(IGL-MYC)3Hm
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most mice hemizygous for the transgene die between the ages of 2 and 6 months

immune system
• transgene hemizygotes develop severe lymphadenopathy, but only minimal splenomegaly

tumorigenesis
• hemizygous transgenics develop clonal B-lineage lymphomas; their spleens and lymph nodes contain "uniform populations of IgM+CD19+CD5-CD23- cells"

Mouse Models of Human Disease
OMIM IDRef(s)
Burkitt Lymphoma; BL 113970 J:65245