Mouse Genome Informatics
cx1
     Shmt1Gt(AD0236)Wtsi/Shmt1Gt(AD0236)Wtsi
Tg(IGL-MYC)3Hm/0
B6.Cg-Shmt1Gt(AD0236)Wtsi Tg(IGL-MYC)3Hm
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
increased tumor growth/size ( J:183477 )
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice


Mouse Genome Informatics
cx2
     Ldhaa-m1Neu/Ldhaa-m1Neu
Tg(IGL-MYC)3Hm/0
involves: 101/El * C3H/El * C57BL/6N
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
increased tumor growth/size ( J:183477 )
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice


Mouse Genome Informatics
tg3
     Tg(IGL-MYC)3Hm/0
C57BL/6N-Tg(IGL-MYC)3Hm
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
premature death ( J:65245 )
• most mice hemizygous for the transgene die between the ages of 2 and 6 months

immune system
enlarged lymph nodes ( J:65245 )
• transgene hemizygotes develop severe lymphadenopathy, but only minimal splenomegaly

tumorigenesis
B cell derived lymphoma ( J:65245 )
• hemizygous transgenics develop clonal B-lineage lymphomas; their spleens and lymph nodes contain "uniform populations of IgM+CD19+CD5-CD23- cells"

Mouse Models of Human Disease
 OMIM IDRef(s)
Burkitt Lymphoma; BL 113970 J:65245