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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat1m1Btlr
mutation 1, Bruce Beutler
MGI:3619019
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat1m1Btlr/Stat1m1Btlr C57BL/6J-Stat1m1Btlr MGI:3619020
cx2
 		Ptpn6m1Btlr/Ptpn6m1Btlr
Stat1m1Btlr/Stat1m1Btlr 		C57BL/6J-Stat1m1Btlr Ptpn6m1Btlr MGI:3822472


Genotype
MGI:3619020
hm1
Allelic
Composition		 Stat1m1Btlr/Stat1m1Btlr
Genetic
Background		 C57BL/6J-Stat1m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1m1Btlr mutation (1 available); any Stat1 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:105543 )
• the hypersusceptibility of homozygous mutant macrophages to vesicular stomatitis virus (VSV) infection ex vivo is not corrected by addition of type I interferon to the culture
increased susceptibility to Herpesvirales infection ( J:105543 )
• mice homozygous for the mutation are unusually susceptible to infection by mouse cytomegalovirus (MCMV)
• 50% mortality at day 4 following MCMV infection; 100% mortality at 4.5 days
increased susceptibility to Riboviria infection ( J:105543 )
• macrophages of homozygous mutant mice are hypersusceptible to ex vivo infection by vesicular stomatitis virus (VSV)

hematopoietic system
abnormal macrophage physiology ( J:105543 )
• the hypersusceptibility of homozygous mutant macrophages to vesicular stomatitis virus (VSV) infection ex vivo is not corrected by addition of type I interferon to the culture




Genotype
MGI:3822472
cx2
Allelic
Composition		 Ptpn6m1Btlr/Ptpn6m1Btlr
Stat1m1Btlr/Stat1m1Btlr
Genetic
Background		 C57BL/6J-Stat1m1Btlr Ptpn6m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6m1Btlr mutation (1 available); any Ptpn6 mutation (47 available)
Stat1m1Btlr mutation (1 available); any Stat1 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
ulcerated autopod ( J:142845 )
• Stat1 deficiency does not prevent the plantar inflammation that is a phenotypic characteristic for Ptpn6m1Btlr homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory