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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crebbptm1Jvd
targeted mutation 1, Jan M A van Deursen
MGI:3618462
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crebbptm1Jvd/Crebbptm1Jvd involves: 129 * C57BL/6 MGI:3618582
cn2
 		Crebbptm1Jvd/Crebbptm1Jvd
Tg(Lck-cre)548Jxm/0 		involves: 129 * C57BL/6 * CBA MGI:3618585
cn3
 		Cdkn1btm1Mlf/Cdkn1b+
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0 		involves: 129 * C57BL/6 * CBA * FVB MGI:3618584
cn4
 		Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0 		involves: 129 * C57BL/6 * FVB MGI:3618583
cn5
 		Crebbptm1Jvd/Crebbptm1Jvd
Ep300tm2Pkb/Ep300tm2Pkb
Tg(Lck-cre)548Jxm/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3618581


Genotype
MGI:3618582
hm1
Allelic
Composition		 Crebbptm1Jvd/Crebbptm1Jvd
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Jvd mutation (2 available); any Crebbp mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:88323 )
• indistinguishable from wild-type with normal life spans




Genotype
MGI:3618585
cn2
Allelic
Composition		 Crebbptm1Jvd/Crebbptm1Jvd
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Jvd mutation (2 available); any Crebbp mutation (99 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:105505 )
• reduced about 2 fold in peripheral blood
decreased thymocyte number ( J:105505 )
• total number of thymocytes significantly reduced
decreased CD4-positive, alpha-beta T cell number ( J:105505 )
• reduced in numbers but normal numbers of CD8+ cells

neoplasm
increased T cell derived lymphoma incidence ( J:105505 )
• appear as early as 16 weeks of age

hematopoietic system
decreased T cell number ( J:105505 )
• reduced about 2 fold in peripheral blood
decreased thymocyte number ( J:105505 )
• total number of thymocytes significantly reduced
decreased CD4-positive, alpha-beta T cell number ( J:105505 )
• reduced in numbers but normal numbers of CD8+ cells

endocrine/exocrine glands
decreased thymocyte number ( J:105505 )
• total number of thymocytes significantly reduced
increased T cell derived lymphoma incidence ( J:105505 )
• appear as early as 16 weeks of age




Genotype
MGI:3618584
cn3
Allelic
Composition		 Cdkn1btm1Mlf/Cdkn1b+
Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Mlf mutation (2 available); any Cdkn1b mutation (25 available)
Crebbptm1Jvd mutation (2 available); any Crebbp mutation (99 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:88323 )
• considerably accelerated tumor development

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:88323 )
• considerably accelerated tumor development




Genotype
MGI:3618583
cn4
Allelic
Composition		 Crebbptm1Jvd/Crebbptm1Jvd
Tg(MMTV-cre)4Mam/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Jvd mutation (2 available); any Crebbp mutation (99 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased double-positive T cell number ( J:88323 )
• decreased percentage of double positive cells
increased CD8-positive, alpha-beta T cell number ( J:88323 )
• increased percentage of CD8-SP thymocytes

neoplasm
increased T cell derived lymphoma incidence ( J:88323 )
• 59% of mice develop fatal T-cell lymphomas between 3 and 9 months of age
• remaining animals continue healthy past 10 months of age

hematopoietic system
decreased double-positive T cell number ( J:88323 )
• decreased percentage of double positive cells
increased CD8-positive, alpha-beta T cell number ( J:88323 )
• increased percentage of CD8-SP thymocytes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:88323 )
• 59% of mice develop fatal T-cell lymphomas between 3 and 9 months of age
• remaining animals continue healthy past 10 months of age




Genotype
MGI:3618581
cn5
Allelic
Composition		 Crebbptm1Jvd/Crebbptm1Jvd
Ep300tm2Pkb/Ep300tm2Pkb
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Jvd mutation (2 available); any Crebbp mutation (99 available)
Ep300tm2Pkb mutation (2 available); any Ep300 mutation (97 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell number ( J:105505 )
• drop in number of single positive thymocytes comparable to the increase in double negative cells
• no increase in CD8+ single positive thymocytes
• near absence of single positive thymocytes in the periphery
increased double-negative T cell number ( J:105505 )
• 10 fold increase in the percentage of double negative thymocytes
decreased double-positive T cell number ( J:105505 )
• near absence in the periphery

hematopoietic system
abnormal T cell number ( J:105505 )
• drop in number of single positive thymocytes comparable to the increase in double negative cells
• no increase in CD8+ single positive thymocytes
• near absence of single positive thymocytes in the periphery
increased double-negative T cell number ( J:105505 )
• 10 fold increase in the percentage of double negative thymocytes
decreased double-positive T cell number ( J:105505 )
• near absence in the periphery




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory