Mouse Genome Informatics
ht1
    Rr27tm4Msb/H19+
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• at E13.5, embryos are 18% heavier than controls when maternally inherited
• at E9.5, embyros are indistiguishable from controls

embryogenesis
• at E13.5, embryos are 18% heavier than controls when maternally inherited
• at E9.5, embyros are indistiguishable from controls
• at E13.5, placentas were 40% heavier than controls when maternally inherited
• at E9.5, placenta size is similar to controls

cellular
• when paternally inherited, the paternal H19 locus is derepressed and the paternally inherited Igf2 is repressed
• when maternally inherited, the maternal H19 gene is repressed and the Igf2 gene is activated
• embryonic methylataion of the H19 prometer and 5' end is lost