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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rr27tm4Msb
targeted mutation 4, Marisa S Bartolomei
MGI:3617971
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Rr27tm4Msb/Rr27+ involves: 129P2/OlaHsd * C57BL/6J MGI:3620117


Genotype
MGI:3620117
ht1
Allelic
Composition
Rr27tm4Msb/Rr27+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr27tm4Msb mutation (1 available); any Rr27 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at E13.5, embryos are 18% heavier than controls when maternally inherited
• at E9.5, embyros are indistiguishable from controls

embryo
• at E13.5, embryos are 18% heavier than controls when maternally inherited
• at E9.5, embyros are indistiguishable from controls
• at E13.5, placentas were 40% heavier than controls when maternally inherited
• at E9.5, placenta size is similar to controls

cellular
• when paternally inherited, the paternal H19 locus is derepressed and the paternally inherited Igf2 is repressed
• when maternally inherited, the maternal H19 gene is repressed and the Igf2 gene is activated
• embryonic methylataion of the H19 prometer and 5' end is lost





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory