Mouse Genome Informatics
hm1
    Cpt1btm1You/Cpt1btm1You
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no homozygous embryos are found at E9.5-11.5


Mouse Genome Informatics
ht2
    Cpt1btm1You/Cpt1b+
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
N
• normal fasting blood glucose concentration (J:131341)
• 7% of heterozygous mice (n = 30) developed fatal hypothermia following a 3 h cold challenge, while none of the control mice (n = 30) were affected
• with a prolonged cold challenge (6 h), significantly more heterozygous mice developed fatal hypothermia (52% heterozygous mice vs. 21% control mice)
• with a prolonged cold challenge (6 h), an increased frequency of fatal hypothermia in females of both genotypes (67% female vs. 38% male heterozygous mice, and 33% female vs. 8% male control mice) is observed