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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cpt1btm1You
targeted mutation 1, Yun You
MGI:3617815
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cpt1btm1You/Cpt1btm1You involves: 129X1/SvJ * C57BL/6J MGI:3715235
ht2
Cpt1btm1You/Cpt1b+ involves: 129X1/SvJ * C57BL/6J MGI:4421419


Genotype
MGI:3715235
hm1
Allelic
Composition
Cpt1btm1You/Cpt1btm1You
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt1btm1You mutation (0 available); any Cpt1b mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous embryos are found at E9.5-11.5 (J:131341)
• no homozygous embryos are found at E9.5-11.5 (J:131341)




Genotype
MGI:4421419
ht2
Allelic
Composition
Cpt1btm1You/Cpt1b+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt1btm1You mutation (0 available); any Cpt1b mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• normal fasting blood glucose concentration (J:131341)
• normal fasting blood glucose concentration (J:131341)
• 7% of heterozygous mice (n = 30) developed fatal hypothermia following a 3 h cold challenge, while none of the control mice (n = 30) were affected (J:131341)
• with a prolonged cold challenge (6 h), significantly more heterozygous mice developed fatal hypothermia (52% heterozygous mice vs. 21% control mice) (J:131341)
• with a prolonged cold challenge (6 h), an increased frequency of fatal hypothermia in females of both genotypes (67% female vs. 38% male heterozygous mice, and 33% female vs. 8% male control mice) is observed (J:131341)
• 7% of heterozygous mice (n = 30) developed fatal hypothermia following a 3 h cold challenge, while none of the control mice (n = 30) were affected (J:131341)
• with a prolonged cold challenge (6 h), significantly more heterozygous mice developed fatal hypothermia (52% heterozygous mice vs. 21% control mice) (J:131341)
• with a prolonged cold challenge (6 h), an increased frequency of fatal hypothermia in females of both genotypes (67% female vs. 38% male heterozygous mice, and 33% female vs. 8% male control mice) is observed (J:131341)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory