Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
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nervous system
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• corpus callosum axonal projections are disrupted; decussation of interhemispheric corpus callosal axons is abnormal and axons fail to cross the midline
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• Probst bundles are present in mutants
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• homozygous mice display an absence of the corpus callosum
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• hippocampal commissure is absent
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cellular
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• corpus callosum axonal projections are disrupted; decussation of interhemispheric corpus callosal axons is abnormal and axons fail to cross the midline
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Allelic Composition |
Dclk1tm1.1Jgg/Dclk1+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
|
|
|
nervous system
|
• alterations in corpus callosum thickness are observed in heterozygotes with the appearance of small Probst bundles
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
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mortality/aging
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• pups die before weaning, usually shortly after birth
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nervous system
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• corpus callosum is absent
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• anterior commissure is hypoplastic
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• a cortical lamination defect, most notable in the lateral cortex is apparent
• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3
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Allelic Composition |
Dclk1tm1.1Jgg/Dclk1+ Dcxtm1Caw/Y
|
|
Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
nervous system
|
• corpus callosum is hypoplastic
|
|
• anterior commissure is severely reduced in thickness
|
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• cortical neuron distribution is altered, with neurons showing a much broader pattern of distribution
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
mortality/aging
|
• pups die before weaning, usually soon after birth
|
nervous system
|
• corpus callosum is absent
|
|
• there is no apparent laminar structure to the cortex
|
|
• cortical neuron distribution is altered, showing a broader pattern of distribution
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
nervous system
|
• corpus callosum is absent
|
|
• anterior commissure is hypoplastic
|
|
• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation
(0 available);
any
Dclk1 mutation
(53 available)
Dcxtm1Caw mutation
(0 available);
any
Dcx mutation
(18 available)
|
|
|
nervous system
|
• corpus callosum is absent
|