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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dclk1tm1.1Jgg
targeted mutation 1.1, Joseph G Gleeson
MGI:3617379
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618306
ht2
Dclk1tm1.1Jgg/Dclk1+ involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618287
cx3
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Y
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618307
cx4
Dclk1tm1.1Jgg/Dclk1+
Dcxtm1Caw/Y
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618308
cx5
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Dcxtm1Caw
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618309
cx6
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Dcx+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618310
cx7
Dclk1tm1.1Jgg/Dclk1+
Dcxtm1Caw/Dcxtm1Caw
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618311


Genotype
MGI:3618306
hm1
Allelic
Composition
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• corpus callosum axonal projections are disrupted; decussation of interhemispheric corpus callosal axons is abnormal and axons fail to cross the midline
• Probst bundles are present in mutants
• homozygous mice display an absence of the corpus callosum
• hippocampal commissure is absent

cellular
• corpus callosum axonal projections are disrupted; decussation of interhemispheric corpus callosal axons is abnormal and axons fail to cross the midline




Genotype
MGI:3618287
ht2
Allelic
Composition
Dclk1tm1.1Jgg/Dclk1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• alterations in corpus callosum thickness are observed in heterozygotes with the appearance of small Probst bundles




Genotype
MGI:3618307
cx3
Allelic
Composition
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die before weaning, usually shortly after birth

nervous system
• corpus callosum is absent
• anterior commissure is hypoplastic
• a cortical lamination defect, most notable in the lateral cortex is apparent
• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3




Genotype
MGI:3618308
cx4
Allelic
Composition
Dclk1tm1.1Jgg/Dclk1+
Dcxtm1Caw/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• corpus callosum is hypoplastic
• anterior commissure is severely reduced in thickness
• cortical neuron distribution is altered, with neurons showing a much broader pattern of distribution




Genotype
MGI:3618309
cx5
Allelic
Composition
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Dcxtm1Caw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die before weaning, usually soon after birth

nervous system
• corpus callosum is absent
• there is no apparent laminar structure to the cortex
• cortical neuron distribution is altered, showing a broader pattern of distribution




Genotype
MGI:3618310
cx6
Allelic
Composition
Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Dcx+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• corpus callosum is absent
• anterior commissure is hypoplastic
• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3




Genotype
MGI:3618311
cx7
Allelic
Composition
Dclk1tm1.1Jgg/Dclk1+
Dcxtm1Caw/Dcxtm1Caw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (53 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• corpus callosum is absent





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory