All Phenotypes Notch2<tm3.1Grid> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch2^tm3.1Grid
targeted mutation 3.1, Tom Gridley
MGI:3617329

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch2^tm3.1Grid/Notch2^tm3.1Grid	involves: 129S1/Sv * C57BL/6J	MGI:3617906
cn2	Notch2^tm3Grid/Notch2^tm3.1Grid Pax3^tm1(cre)Joe/Pax3⁺	involves: 129 * C57BL/6	MGI:3778204
cn3	Notch2^tm3Grid/Notch2^tm3.1Grid Tg(Tagln-cre)1Her/?	involves: 129 * C57BL/6	MGI:3778203
cn4	Notch2^tm3Grid/Notch2^tm3.1Grid Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * C57BL/6 * DBA	MGI:3778811
cx5	Jag1^tm1Grid/Jag1⁺ Notch2^tm3.1Grid/Notch2⁺	B6.129S1-Jag1^tm1Grid Notch2^tm3.1Grid	MGI:5004909
cx6	Notch2^tm3.1Grid/Notch2⁺ Poglut1^{Gt(IST10323G11)Tigm}/Poglut1⁺	B6.Cg-Notch2^tm3.1Grid Poglut1^{Gt(IST10323G11)Tigm}	MGI:5004912
cx7	Notch1^tm1Con/Notch1⁺ Notch2^tm3.1Rko/Notch2^tm3.1Grid	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5523684

Allelic Composition	Notch2^tm3.1Grid/Notch2^tm3.1Grid
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:105278 )

• none survive beyond E11.5

growth/size/body

embryonic growth retardation ( J:105278 )

• at E10.5

cardiovascular system

pericardial edema ( J:105278 )

• at E10.5

abnormal cardiovascular system physiology ( J:105278 )

• cardiovascular dysfunction at E10.5

homeostasis/metabolism

pericardial edema ( J:105278 )

• at E10.5

embryo

embryonic growth retardation ( J:105278 )

• at E10.5

Allelic Composition	Notch2^tm3Grid/Notch2^tm3.1Grid Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)
Notch2^tm3Grid mutation (2 available); any Notch2 mutation (97 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:132939 )

• there is a 50% mortality rate between birth and weaning

cardiovascular system

pulmonary artery stenosis ( J:132939 )

• pulmonary arteries of E18.5 embryos and newborns are significantly smaller

supravalvar pulmonary trunk stenosis ( J:132939 )

• the mean inner diameter of the pulmonary trunk is 1.22 mm compared to 1.56 mm for age-matched controls

aorta stenosis ( J:132939 )

• aorta diameters of all E18.5 embryos and newborns are decreased compared to wild-type mice

• the mean aortic diameter is 1.3 mm compared to 1.5 mm for age-matched controls

abnormal vascular smooth muscle morphology ( J:132939 )

• smooth muscle cell proliferation is reduced to 9% in E16.5 embryos compared to 22.5% of wild-type embryos

craniofacial

abnormal tooth morphology ( J:132939 )

• dental malformations inhibit the ability of mice to feed postnatally

growth/size/body

abnormal tooth morphology ( J:132939 )

• dental malformations inhibit the ability of mice to feed postnatally

decreased body weight ( J:132939 )

• by one week of age, mice weigh significantly less than control littermates

homeostasis/metabolism

cyanosis ( J:132939 )

• a mild cyanotic appearance is observed in neonates

muscle

abnormal vascular smooth muscle morphology ( J:132939 )

• smooth muscle cell proliferation is reduced to 9% in E16.5 embryos compared to 22.5% of wild-type embryos

skeleton

abnormal tooth morphology ( J:132939 )

• dental malformations inhibit the ability of mice to feed postnatally

Allelic Composition	Notch2^tm3Grid/Notch2^tm3.1Grid Tg(Tagln-cre)1Her/?
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:132939 )

• there is a 50% mortality rate between birth and weaning

cardiovascular system

pulmonary artery stenosis ( J:132939 )

• pulmonary arteries of E18.5 embryos and newborns are significantly smaller

aorta stenosis ( J:132939 )

• aorta diameters of all E18.5 embryos and newborns are decreased compared to wild-type mice

abnormal blood flow velocity ( J:132939 )

• mean aortic velocity in one month old mice is 1.74 m/s which is significantly faster than the mean velocity of 0.93 m/s for controls

• mean pulmonary velocity in one month old mice is 1.9 m/s which is significantly faster than the mean velocity of 1.5 m/s for controls

homeostasis/metabolism

cyanosis ( J:132939 )

• is observed in neonates

Allelic Composition	Notch2^tm3Grid/Notch2^tm3.1Grid Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)
Notch2^tm3Grid mutation (2 available); any Notch2 mutation (97 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

focal hepatic necrosis ( J:133171 )

abnormal bile duct morphology ( J:133171 )

• by P7 few bile ducts are present

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:133171 )

N	• blood urea nitrogen levels are normal

increased circulating bilirubin level ( J:133171 )

• in some mice

increased circulating alanine transaminase level ( J:133171 )

• in some mice

increased circulating alkaline phosphatase level ( J:133171 )

• in some mice

growth/size/body

decreased body size ( J:133171 )

decreased body weight ( J:133171 )

• at P8 to P9, mice are 19% lighter than wild-type

• at 4 to 5 weeks of age, mice are 15% lighter than wild-type

endocrine/exocrine glands

abnormal bile duct morphology ( J:133171 )

• by P7 few bile ducts are present

cellular

focal hepatic necrosis ( J:133171 )

Allelic Composition	Jag1^tm1Grid/Jag1⁺ Notch2^tm3.1Grid/Notch2⁺
Genetic Background	B6.129S1-Jag1^tm1Grid Notch2^tm3.1Grid

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1^tm1Grid mutation (1 available); any Jag1 mutation (76 available)
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal biliary tract morphology ( J:171432 )

• severe decrease in the number of biliary cells in the periportal regions at P0

abnormal bile duct morphology ( J:171432 )

• bile duct paucity at P0

endocrine/exocrine glands

abnormal bile duct morphology ( J:171432 )

• bile duct paucity at P0

Allelic Composition	Notch2^tm3.1Grid/Notch2⁺ Poglut1^{Gt(IST10323G11)Tigm}/Poglut1⁺
Genetic Background	B6.Cg-Notch2^tm3.1Grid Poglut1^{Gt(IST10323G11)Tigm}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)
Poglut1^{Gt(IST10323G11)Tigm} mutation (0 available); any Poglut1 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:171432 )

N	• do not show bile duct abnormalities

Allelic Composition	Notch1^tm1Con/Notch1⁺ Notch2^tm3.1Rko/Notch2^tm3.1Grid
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)
Notch2^tm3.1Rko mutation (0 available); any Notch2 mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:198632 )

N	• kidneys have functional nephrons in normal numbers; one copy of the Notch1 intracellular domain (N1ICD) expressed from the Notch2 locus is sufficient for nephron formation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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