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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nox1tm1Kkr
targeted mutation 1, Karl-Heinz Krause
MGI:3616995
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Nox1tm1Kkr/Y B6.129X1-Nox1tm1Kkr MGI:3617189


Genotype
MGI:3617189
ot1
Allelic
Composition
Nox1tm1Kkr/Y
Genetic
Background
B6.129X1-Nox1tm1Kkr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nox1tm1Kkr mutation (1 available); any Nox1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice show decreased hypertrophy in the aorta in response to prolonged angiotensin II application
• in response to angiotensin II, there is decrease extracellular matrix protein accumulation in mutants and matrix proteins remain as fine lining along the elastic fibers rather than being found in abundant patches in the aortic media as in wild-type mice
• basal systolic blood pressure is slightly but significantly decreased (108+/-15mm Hg vs. 116+/-12mm Hg in wild-type, p=0.03) compared to wild-type
• in response to angiotensin II, hemizygous males showed an initial increase in systolic blood pressure at day 3 but return to basal levels by day 6, unlike wild-type mice in which sytolic blood pressure remains elevated
• null male mice display lower levels of reactive oxygen species in the aortic media in response to angiotensin II-induced oxidative stress, compared to wild-type mice

homeostasis/metabolism
• angiotensin II induces a 4-fold increase in NOX2 in mutants compared with wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory