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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Atoh1-cre/Esr1*)14Fsh
transgene insertion 14, Gordon Fishell
MGI:3615691
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cacna1atm1.1Ehess/Cacna1atm2.1Maag
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5707186
cn2
Ric8atm1Aks/Ric8atm1.1Zhua
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129P2/OlaHsd * FVB/N MGI:5467517
cn3
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129T2/SvEms * FVB/N MGI:5286071
cn4
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129X1/SvJ * FVB/N MGI:3810322
cn5
Bicd2tm1Hgrd/Bicd2tm1Hgrd
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: C57BL/6 * FVB/N MGI:5810139
cn6
Ythdf1tm1.1Sjj/Ythdf1tm1.1Sjj
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: FVB/N MGI:6719337
cn7
Eya1tm2Px/Eya1tm2Px
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: FVB/N MGI:5316867
cn8
Six1tm1Px/Six1tm1Px
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: FVB/N MGI:5316868
tg9
Tg(Atoh1-cre/Esr1*)14Fsh/0 involves: FVB/N * Swiss Webster MGI:4452029


Genotype
MGI:5707186
cn1
Allelic
Composition
Cacna1atm1.1Ehess/Cacna1atm2.1Maag
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1atm1.1Ehess mutation (1 available); any Cacna1a mutation (85 available)
Cacna1atm2.1Maag mutation (0 available); any Cacna1a mutation (85 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not exhibit motor dysfunction on the rotarod




Genotype
MGI:5467517
cn2
Allelic
Composition
Ric8atm1Aks/Ric8atm1.1Zhua
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8atm1.1Zhua mutation (0 available); any Ric8a mutation (23 available)
Ric8atm1Aks mutation (0 available); any Ric8a mutation (23 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• granule cell precursors are normal in tamoxifen-treated mice




Genotype
MGI:5286071
cn3
Allelic
Composition
Ptch1tm1Bjw/Ptch1tm1Bjw
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: 129T2/SvEms * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Bjw mutation (2 available); any Ptch1 mutation (88 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 10 weeks, mice start becoming severely ill and must be sacrificed
• all mice die by 29 weeks of age

nervous system
• granule neuron precursors in mice treated with tamoxifen at P4 exhibit increased proliferation unlike in wild-type mice
• in all mice treated with tamoxifen at E14.5 with a median age of tumor onset at 10 weeks
• in all mice treated with tamoxifen at P4 with a median age of tumor onset at 13 weeks
• in all mice treated with tamoxifen at P8 with a median age of tumor onset at 15.5 weeks
• in 29% of mice treated with tamoxifen at P10 with a median age of tumor onset at 19 weeks
• however, mice treated with tamoxifen at E10.5, at P12, or later than P12 do not develop tumors
• at P21 in mice treated with tamoxifen at P4
• cerebellar hyperplasia at 10 weeks of age

neoplasm
• in all mice treated with tamoxifen at E14.5 with a median age of tumor onset at 10 weeks
• in all mice treated with tamoxifen at P4 with a median age of tumor onset at 13 weeks
• in all mice treated with tamoxifen at P8 with a median age of tumor onset at 15.5 weeks
• in 29% of mice treated with tamoxifen at P10 with a median age of tumor onset at 19 weeks
• however, mice treated with tamoxifen at E10.5, at P12, or later than P12 do not develop tumors

cellular
• granule neuron precursors in mice treated with tamoxifen at P4 exhibit increased proliferation unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:139573




Genotype
MGI:3810322
cn4
Allelic
Composition
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice survive 41 days

nervous system
• all mice develop diffuse medulloblastomas and have a mean survival of 41 days
• mice exhibit hyperplasia on the external granule cell layer beginning at P0 and more prominently at P7

neoplasm
• all mice develop diffuse medulloblastomas and have a mean survival of 41 days

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:139574




Genotype
MGI:5810139
cn5
Allelic
Composition
Bicd2tm1Hgrd/Bicd2tm1Hgrd
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicd2tm1Hgrd mutation (0 available); any Bicd2 mutation (22 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
N
• tamoxifen-treated mice survive to >8 weeks (when they are sacrificed) and do not exhibit hydrocephalus or disrupted laminar organization in the cerebral cortex, cerebellum or hippocampus
• at P25, all post-migratory granule cells are found in the cerebellar internal granule cell layer, indicating that cerebellar granule cell migration is normal




Genotype
MGI:6719337
cn6
Allelic
Composition
Ythdf1tm1.1Sjj/Ythdf1tm1.1Sjj
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
Ythdf1tm1.1Sjj mutation (0 available); any Ythdf1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• embryos exhibit defects in pre-crossing commissural axon guidance, with significantly more commissural axons misprojecting into motor columns at E11.5
• pre-crossing axon guidance defects include stalling and pre-crossing turning phenotypes
• however, patterning of the spinal cord and development of dI1 commissural neurons is normal

homeostasis/metabolism
• when dorsal spinal cord (DSC) explants are dissected from pre-crossing E10.5 spinal cord and cultured in vitro, dorsal commissural axons show a dramatic reduction in Robo3.1 protein level relative to controls
• however, Robo3.1 mRNA level is not affected in the spinal cord

cellular
• embryos exhibit defects in pre-crossing commissural axon guidance, with significantly more commissural axons misprojecting into motor columns at E11.5
• pre-crossing axon guidance defects include stalling and pre-crossing turning phenotypes
• however, patterning of the spinal cord and development of dI1 commissural neurons is normal




Genotype
MGI:5316867
cn7
Allelic
Composition
Eya1tm2Px/Eya1tm2Px
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eya1tm2Px mutation (0 available); any Eya1 mutation (42 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• hair cells in the basal and medial turns of the cochlea from tamoxifen-treated mice exhibit abnormalities that disappear when cultured in vitro
• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows
• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows

nervous system
• hair cells in the basal and medial turns of the cochlea from tamoxifen-treated mice exhibit abnormalities that disappear when cultured in vitro
• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows
• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows




Genotype
MGI:5316868
cn8
Allelic
Composition
Six1tm1Px/Six1tm1Px
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six1tm1Px mutation (0 available); any Six1 mutation (17 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• authors state that tamoxifen-treated mice exhibit the same phenotype as in Eya1tm2Px/Eya1tm2Px Tg(Atoh1-cre/Esr1*)14Fsh mice

nervous system
• authors state that tamoxifen-treated mice exhibit the same phenotype as in Eya1tm2Px/Eya1tm2Px Tg(Atoh1-cre/Esr1*)14Fsh mice




Genotype
MGI:4452029
tg9
Allelic
Composition
Tg(Atoh1-cre/Esr1*)14Fsh/0
Genetic
Background
involves: FVB/N * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-cre/Esr1*)14Fsh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory