Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1atm1.1Ehess mutation
(0 available);
any
Cacna1a mutation
(115 available)
Cacna1atm2.1Maag mutation
(0 available);
any
Cacna1a mutation
(115 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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behavior/neurological
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N |
• mice do not exhibit motor dysfunction on the rotarod
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ric8atm1.1Zhua mutation
(0 available);
any
Ric8a mutation
(29 available)
Ric8atm1Aks mutation
(0 available);
any
Ric8a mutation
(29 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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nervous system
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N |
• granule cell precursors are normal in tamoxifen-treated mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Bjw mutation
(2 available);
any
Ptch1 mutation
(115 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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mortality/aging
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• by 10 weeks, mice start becoming severely ill and must be sacrificed
• all mice die by 29 weeks of age
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nervous system
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• granule neuron precursors in mice treated with tamoxifen at P4 exhibit increased proliferation unlike in wild-type mice
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• in all mice treated with tamoxifen at E14.5 with a median age of tumor onset at 10 weeks
• in all mice treated with tamoxifen at P4 with a median age of tumor onset at 13 weeks
• in all mice treated with tamoxifen at P8 with a median age of tumor onset at 15.5 weeks
• in 29% of mice treated with tamoxifen at P10 with a median age of tumor onset at 19 weeks
• however, mice treated with tamoxifen at E10.5, at P12, or later than P12 do not develop tumors
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• at P21 in mice treated with tamoxifen at P4
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• cerebellar hyperplasia at 10 weeks of age
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neoplasm
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• in all mice treated with tamoxifen at E14.5 with a median age of tumor onset at 10 weeks
• in all mice treated with tamoxifen at P4 with a median age of tumor onset at 13 weeks
• in all mice treated with tamoxifen at P8 with a median age of tumor onset at 15.5 weeks
• in 29% of mice treated with tamoxifen at P10 with a median age of tumor onset at 19 weeks
• however, mice treated with tamoxifen at E10.5, at P12, or later than P12 do not develop tumors
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cellular
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• granule neuron precursors in mice treated with tamoxifen at P4 exhibit increased proliferation unlike in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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mortality/aging
nervous system
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• all mice develop diffuse medulloblastomas and have a mean survival of 41 days
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• mice exhibit hyperplasia on the external granule cell layer beginning at P0 and more prominently at P7
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neoplasm
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• all mice develop diffuse medulloblastomas and have a mean survival of 41 days
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicd2tm1Hgrd mutation
(0 available);
any
Bicd2 mutation
(31 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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normal phenotype
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• tamoxifen-treated mice survive to >8 weeks (when they are sacrificed) and do not exhibit hydrocephalus or disrupted laminar organization in the cerebral cortex, cerebellum or hippocampus
• at P25, all post-migratory granule cells are found in the cerebellar internal granule cell layer, indicating that cerebellar granule cell migration is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7tm2c(EUCOMM)Wtsi mutation
(0 available);
any
Chd7 mutation
(136 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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hearing/vestibular/ear
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N |
• tamoxifen treatment at E16 does not result in postnatal hair cell degeneration unlike in mice where recombinase is active in the early embryonic period
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six1tm1Px mutation
(0 available);
any
Six1 mutation
(18 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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hearing/vestibular/ear
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• authors state that tamoxifen-treated mice exhibit the same phenotype as in Eya1tm2Px/Eya1tm2Px Tg(Atoh1-cre/Esr1*)14Fsh mice
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nervous system
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• authors state that tamoxifen-treated mice exhibit the same phenotype as in Eya1tm2Px/Eya1tm2Px Tg(Atoh1-cre/Esr1*)14Fsh mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
Ythdf1tm1.1Sjj mutation
(0 available);
any
Ythdf1 mutation
(36 available)
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nervous system
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• embryos exhibit defects in pre-crossing commissural axon guidance, with significantly more commissural axons misprojecting into motor columns at E11.5
• pre-crossing axon guidance defects include stalling and pre-crossing turning phenotypes
• however, patterning of the spinal cord and development of dI1 commissural neurons is normal
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homeostasis/metabolism
cellular
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• embryos exhibit defects in pre-crossing commissural axon guidance, with significantly more commissural axons misprojecting into motor columns at E11.5
• pre-crossing axon guidance defects include stalling and pre-crossing turning phenotypes
• however, patterning of the spinal cord and development of dI1 commissural neurons is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eya1tm2Px mutation
(0 available);
any
Eya1 mutation
(54 available)
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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hearing/vestibular/ear
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• hair cells in the basal and medial turns of the cochlea from tamoxifen-treated mice exhibit abnormalities that disappear when cultured in vitro
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• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows
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• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows
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nervous system
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• hair cells in the basal and medial turns of the cochlea from tamoxifen-treated mice exhibit abnormalities that disappear when cultured in vitro
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• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows
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• tamoxifen-treated mice lack hair cells in the apical turn of the cochlea with outer rows more affected than inner rows
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-cre/Esr1*)14Fsh mutation
(1 available)
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Analysis Tools
