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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(11Irf1-D11Mit23)1Rub
deletion, Chr 11, Edward M Rubin 1
MGI:3614966
Summary 3 genotypes


Genotype
MGI:3614973
hm1
Allelic
Composition
Del(11Irf1-D11Mit23)1Rub/Del(11Irf1-D11Mit23)1Rub
Genetic
Background
129/Sv-Del(11Irf1-D11Mit23)1Rub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(11Irf1-D11Mit23)1Rub mutation (2 available); any Del(11Irf1-D11Mit23)1Rub mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes die by 6 weeks of age; the longest survivor lived 30 weeks

growth/size/body
• at 28 days of age, the weight of homozygous mice is only about two-thirds that of wild-type or hemizygous mice

liver/biliary system
• liver triglyceride content of 28 day old homozygotes is dramatically elevated - approximately 5-fold - while hepatic total cholesterol is only slightly raised relative to that of wild-type and hemizygous mice
• by 1 day of age, homozygotes exhibit swollen abdomens due to extreme hepatomegaly
• at 28 days of age, livers of homozygous mice are enlarged more than two-fold, relative to body weight, compared to those of wild-type or hemizygous mice
• microscopic examination of stained liver sections from chow-fed 28 day old homozygotes reveals cytosolic accumulation of lipid
• livers of chow-fed 28 day old homozygous mice appear pale

homeostasis/metabolism
• carnitine levels are reduced more than 4-fold in plasma of homozygotes relative to wild-type mice
• plasma free fatty acid levels of 28 day old homozygous mice are greatly elevated - approximately 5-fold - compared to those of wild-type and hemizygous mice
• heart triglyceride content of 28 day old homozygous mice is significantly elevated, while total cholesterol in homozygous hearts is only slightly raised compared to measurements for wild-type and hemizygous mice
• plasma triglyceride levels of 28 day old homozygotes are dramatically elevated - up to 10-fold - relative to those of wild-type and hemizygous mice
• the excess plasma triglycerides of homozygous mice are largely confined to the very low density lipoprotein (VLDL) fraction [TAS]
• timed plasma triglyceride measurements under conditions of impaired lipolysis and VLDL triglyceride clearance demonstrate approximately 3-fold higher rates of hepatic VLDL triglyceride secretion in homozygous mice than in wild-type mice; untreated homozygous mice have normal hepatic and lipoprotein lipase activities and hepatic VLDL triglyceride clearance
• liver triglyceride content of 28 day old homozygotes is dramatically elevated - approximately 5-fold - while hepatic total cholesterol is only slightly raised relative to that of wild-type and hemizygous mice

cardiovascular system
• at 28 days of age, hearts of homozygous mice are enlarged 2- to 3-fold relative to body weight in comparison to those of both wild-type and hemizygous mice




Genotype
MGI:3614993
ht2
Allelic
Composition
Del(11Irf1-D11Mit23)1Rub/+
Genetic
Background
129/Sv-Del(11Irf1-D11Mit23)1Rub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(11Irf1-D11Mit23)1Rub mutation (2 available); any Del(11Irf1-D11Mit23)1Rub mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• carnitine levels are reduced by about 20-25% in plasma of deletion hemizygotes relative to wild-type mice
• timed plasma triglyceride measurements under conditions of impaired lipolysis and VLDL triglyceride clearance demonstrate approximately twice the wild-type rate of hepatic VLDL triglyceride secretion in hemizygous deletant mice




Genotype
MGI:5085327
cx3
Allelic
Composition
Del(11Irf1-D11Mit23)1Rub/Del(11Irf1-D11Mit23)1Rub
Tg(A94G6)1Rub/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(11Irf1-D11Mit23)1Rub mutation (2 available); any Del(11Irf1-D11Mit23)1Rub mutation (2 available)
Tg(A94G6)1Rub mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutant mice appear phenotypically normal; transgene expression rescues multiple abnormalities in body weight, liver and heart size, lifespan and triglyceride levels





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory