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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
F10tm1Edr
targeted mutation 1, Elliot D Rosen
MGI:3613747
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
F10tm1Edr/F10tm1Edr involves: 129S1/Sv * 129X1/SvJ * Swiss MGI:3614345


Genotype
MGI:3614345
hm1
Allelic
Composition
F10tm1Edr/F10tm1Edr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F10tm1Edr mutation (0 available); any F10 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• incomplete penetrance; of homozygous mice that are born, 50% die within one day of birth, presumably due to widespread hemorrhage
• of mice that survive the embryonic and neonatal period, most died before P5 from intraabdominal bleeding and some survived as long as P19
• incomplete penetrance; normal Mendelian ratios are present at E9.5, but at E12.5, only 17% of the embryos are homozygous
• resorbed embryos at E9.5 are of all genotypes; at E11.5-12.5, most of the resorbed embryos are homozygous and appear variably as totally disintegrated embryos to nearly normal but white and avascular
• the proportion of homozygous embryos remained constant after E12.5 (16%) until birth

cardiovascular system
N
• no abnormalities in organ or blood vessel development are detected by histochemical analysis
• normal vasculature is observed in E9.5 embryos and their yolk sacs
• embryos that die at E11.5-E12.5 show overt signs of bleeding, including one with massive blood accumulation in the brain ventricles and along the central canal
• postnatal lethality of homozygotes is presumably due to widespread hemorrhages, most frequently intraabdominal bleeding; other areas include subcutaneous, intracranial, peritoneal and dermal bleeding sites





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory