About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccr5tm1Blck
targeted mutation 1, Bruno Luckow
MGI:3613371
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccr5tm1Blck/Ccr5tm1Blck B6.129P2-Ccr5tm1Blck MGI:3614447
cx2
Apoetm1Unc/Apoetm1Unc
Ccr5tm1Blck/Ccr5tm1Blck
involves: 129P2/OlaHsd * C57BL/6 MGI:5317846


Genotype
MGI:3614447
hm1
Allelic
Composition
Ccr5tm1Blck/Ccr5tm1Blck
Genetic
Background
B6.129P2-Ccr5tm1Blck
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5tm1Blck mutation (7 available); any Ccr5 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

immune system
• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes
• survival of transplated cardiac allographs from BALB/c mice into homozygotes is significantly increased and allografts show less tissue remodeling and hence better preservation of myocardial architecture
• carotid artery allografts from BALB/c mice into homozygotes show better tissue preservation and significant reduction of neointima formation and CD3+ T cell infiltration

homeostasis/metabolism
• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

cellular
• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes

hematopoietic system
• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes




Genotype
MGI:5317846
cx2
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ccr5tm1Blck/Ccr5tm1Blck
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (138 available)
Ccr5tm1Blck mutation (7 available); any Ccr5 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced plaque areas after 10-12 weeks on a high fat or high cholesterol diet
• both in the aortic root and the thoracoabdominal artery
• also at 22 weeks when fed a normal diet

immune system
• in atherosclerotic plaques reduced 24% compared to Apoetm1Unc
• monocyte/macrophage in atherosclerotic plaques reduced 77% compared to Apoetm1Unc
• reduced proliferative responses of splenocytes and of lymph node cells by 25% compared to Apoetm1Unc
• significantly decreased secretion by splenocytes
• increased content in atherosclerotic plaques
• increased secretion by both splenocytes and by lymph node cells

hematopoietic system
• in atherosclerotic plaques reduced 24% compared to Apoetm1Unc
• monocyte/macrophage in atherosclerotic plaques reduced 77% compared to Apoetm1Unc
• reduced proliferative responses of splenocytes and of lymph node cells by 25% compared to Apoetm1Unc





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/10/2022
MGI 6.19
The Jackson Laboratory