All Phenotypes Sclt1<Tg(CAG-sb10)1Dla> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sclt1^{Tg(CAG-sb10)1Dla}
transgene insertion 1, David A Largaespada
MGI:3612989

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sclt1^{Tg(CAG-sb10)1Dla}/Sclt1^{Tg(CAG-sb10)1Dla}	FVB/N-Sclt1^{Tg(CAG-sb10)1Dla}	MGI:6110829
cx2	Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0	FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1^{Tg(CAG-sb10)1Dla}	MGI:3613026
cx3	Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)76Dla/0	FVB/N-TgTn(sb-T2/Onc)76Dla Sclt1^{Tg(CAG-sb10)1Dla}	MGI:3613025
cx4	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)76Dla/0	involves: 129X1/SvJ * FVB/N	MGI:3613023
cx5	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0	involves: 129X1/SvJ * FVB/N	MGI:3613024

Allelic Composition	Sclt1^{Tg(CAG-sb10)1Dla}/Sclt1^{Tg(CAG-sb10)1Dla}
Genetic Background	FVB/N-Sclt1^{Tg(CAG-sb10)1Dla}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sclt1^{Tg(CAG-sb10)1Dla} mutation (1 available); any Sclt1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney morphology ( J:243427 )

• paler kidneys by P8

kidney medulla cyst ( J:243427 )

• cysts originate from both collecting and proximal tubule

polycystic kidney ( J:243427 )

• decreased cellularity in cyst-lining epithelium by P21

enlarged kidney ( J:243427 )

• moderately larger kidneys by P8

• 3-fold larger kidneys by P21

renal fibrosis ( J:243427 )

growth/size/body

growth/size/body region phenotype ( J:243427 )

N	• body weight

cleft palate ( J:243427 )

• increased frequency

slow postnatal weight gain ( J:243427 )

• growth retardation by P8

cachexia ( J:243427 )

kidney medulla cyst ( J:243427 )

• cysts originate from both collecting and proximal tubule

polycystic kidney ( J:243427 )

• decreased cellularity in cyst-lining epithelium by P21

enlarged kidney ( J:243427 )

• moderately larger kidneys by P8

• 3-fold larger kidneys by P21

digestive/alimentary system

cleft palate ( J:243427 )

• increased frequency

decreased intestine length ( J:243427 )

homeostasis/metabolism

increased blood urea nitrogen level ( J:243427 )

limbs/digits/tail

preaxial polydactyly ( J:243427 )

• in hind limbs

mortality/aging

premature death ( J:243427 )

• pups die before age 1 month

craniofacial

cleft palate ( J:243427 )

• increased frequency

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease	DOID:0110861	OMIM:263200	J:243427
ciliopathy	DOID:0060340		J:243427

Allelic Composition	Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0
Genetic Background	FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1^{Tg(CAG-sb10)1Dla}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sclt1^{Tg(CAG-sb10)1Dla} mutation (1 available); any Sclt1 mutation (38 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:99991 )

N	• up to 1 year of age no signs of increased tumor susceptibility are seen

Allelic Composition	Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)76Dla/0
Genetic Background	FVB/N-TgTn(sb-T2/Onc)76Dla Sclt1^{Tg(CAG-sb10)1Dla}

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:99991 )

N	• up to 1 year of age no signs of increased tumor susceptibility are seen

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)76Dla/0
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Sclt1^{Tg(CAG-sb10)1Dla} mutation (1 available); any Sclt1 mutation (38 available)
TgTn(sb-T2/Onc)76Dla mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:99991 )

• mice died earlier than those homozygous for Cdkn2a^tm1Cjs alone

neoplasm

increased tumor incidence ( J:99991 )

• tumor spectrum was similar to Cdkn2a^tm1Cjs homozygotes and included malignant meningiomas

increased leukemia incidence ( J:99991 )

• myeloid leukemias were seen

increased lymphoma incidence ( J:99991 )

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

increased sarcoma incidence ( J:99991 )

• soft tissue sarcomas or osteosarcomas

increased osteosarcoma incidence ( J:99991 )

respiratory system

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

skeleton

increased osteosarcoma incidence ( J:99991 )

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:99991 )

• mice died earlier than those homozygous for Cdkn2a^tm1Cjs alone

neoplasm

increased tumor incidence ( J:99991 )

• tumor spectrum was similar to Cdkn2a^tm1Cjs homozygotes and included malignant meningiomas

increased leukemia incidence ( J:99991 )

• myeloid leukemias were seen

increased lymphoma incidence ( J:99991 )

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

increased sarcoma incidence ( J:99991 )

• soft tissue sarcomas or osteosarcomas

increased osteosarcoma incidence ( J:99991 )

respiratory system

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

skeleton

increased osteosarcoma incidence ( J:99991 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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