Analysis Tools
nervous system
| N |
• despite myelination abnormalities, no significant differences in compound muscle action potential amplitudes, nerve conduction velocities or F-wave latencies
|
|
• in the peripheral nerves, mutant mice exhibit a variable and complex degree of myelin infoldings and outfoldings, mainly in the paranodal regions
• defects usually are associated with large caliber axons; small caliber and non-myelinated axons appear unaffected
• defects are progressive with age; rare defects are noted at 3 weeks of age and older mice at 6 months of age tend to have more affected nerve fibers
|
behavior/neurological
|
• rarely, mutant mice exhibit a mild clasping reflex when suspended by the tail
• no other siginificant motor or strength defects were detected
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Charcot-Marie-Tooth disease type 4B1 | DOID:0110191 |
OMIM:601382 |
J:104120 | |
